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It uses ESX\u20101 T7SS to damage phagosomes and to enter the cytosol of host cells after phagocytosis. During infection,\n                    <jats:italic>M. tb<\/jats:italic>\n                    and host mitochondria release dsDNA, which activates the CGAS\u2010STING1 pathway. This pathway leads to the production of type I interferons and proinflammatory cytokines and activates autophagy, which targets and degrades bacteria within autophagosomes. However, the role of type I IFNs in immunity against\n                    <jats:italic>M. tb<\/jats:italic>\n                    is controversial. While previous research has suggested a protective role, recent findings from\n                    <jats:italic>cgas\u2010sting1<\/jats:italic>\n                    knockout mouse studies have contradicted this. Additionally, a study using knockout mice and non\u2010human primate models uncovered a new mechanism by which neutrophils recruited to lung infections form neutrophil extracellular traps. Activating plasmacytoid dendritic cells causes them to produce type I IFNs, which interfere with the function of interstitial macrophages and increase the likelihood of tuberculosis. Notably,\n                    <jats:italic>M. tb<\/jats:italic>\n                    uses its virulence proteins to disrupt the CGAS\u2010STING1 signaling pathway leading to enhanced pathogenesis. Investigating the CGAS\u2010STING1 pathway can help develop new ways to fight tuberculosis.\n                  <\/jats:p>","DOI":"10.1002\/adbi.202400174","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T22:28:44Z","timestamp":1720477724000},"source":"Crossref","is-referenced-by-count":13,"title":["Regulation of Type I Interferon and Autophagy in Immunity against\n                    <i>Mycobacterium Tuberculosis<\/i>\n                    : Role of CGAS and STING1"],"prefix":"10.1002","volume":"8","author":[{"given":"Asrar Ahmad","family":"Malik","sequence":"first","affiliation":[{"name":"Department of Life Sciences Sharda School of Basic Sciences and Research Sharda University  Knowledge Park III Greater Noida Uttar Pradesh 201306 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