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In a disturbed homeostatic condition, hyperactivation of immune cells takes place and interplay between these cells triggers a plethora of signaling pathways, releasing various pro\u2010inflammatory cytokines such as Tumor necrosis factor alpha (TNF\u03b1), Interferon\u2010gamma (IFN\u01b4), Interleukin\u20106 (IL\u20106), and Interleukin\u20101 beta (IL\u20101\u03b2), which marks cytokine storm formation. To be precise, dysregulated balance can impede or increase susceptibility to various pathogens. Pathogens have the ability to hijack the host immune system by interfering with the host's chromatin architecture for their survival and replication in the host cell. Cytokines, particularly IL\u20106, Interleukin\u201017 (IL\u201017), and Interleukin\u201023 (IL\u201023), play a key role in orchestrating innate immune responses and shaping adaptive immunity. Understanding the interplay between immune response and the role of epigenetic modification to maintain immune homeostasis and the structural aspects of IL\u20106, IL\u201017, and IL\u201023 can be illuminating for a novel therapeutic regimen to treat various infectious diseases. In this review, the light is shed on how the orchestration of epigenetic regulation facilitates immune homeostasis.<\/jats:p>","DOI":"10.1002\/adbi.202400278","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:08Z","timestamp":1726185608000},"source":"Crossref","is-referenced-by-count":10,"title":["Innate Immune Response and Epigenetic Regulation: A Closely Intertwined Tale in Inflammation"],"prefix":"10.1002","volume":"9","author":[{"given":"Diksha","family":"Jawale","sequence":"first","affiliation":[{"name":"Systems Medicine Laboratory Biotechnology Research and Innovation Council\u2010National Centre for Cell Science (BRIC\u2010NCCS) NCCS Complex, SPPU Campus, Ganeshkhind Pune 411007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Khandibharad","sequence":"additional","affiliation":[{"name":"Systems Medicine Laboratory Biotechnology Research and Innovation Council\u2010National Centre for Cell Science (BRIC\u2010NCCS) NCCS Complex, SPPU Campus, Ganeshkhind Pune 411007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3817-8819","authenticated-orcid":false,"given":"Shailza","family":"Singh","sequence":"additional","affiliation":[{"name":"Systems Medicine Laboratory Biotechnology Research and Innovation Council\u2010National Centre for Cell Science (BRIC\u2010NCCS) NCCS Complex, SPPU Campus, Ganeshkhind Pune 411007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-01104-y"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0391-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.713758"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.550769"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13060"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2012.01146.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00046-08"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.083001.084359"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.015"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00451-w"},{"key":"e_1_2_6_11_1","first-page":"1","volume":"10","author":"Zhu X.","year":"2022","journal-title":"Front. 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