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Here, the acidic pH typically found in acutely infected wounds can be effectively managed by incorporating a pH\u2010responsive Ag<jats:sup>+<\/jats:sup> loaded system within the hydrogel, thereby ensuring efficient drug use and preventing potential toxicity from the sudden release of silver ions. The antimicrobial composite hydrogel HAMA\/GelMA\u2010CA\/Ag<jats:sup>+<\/jats:sup> provides some tissue adhesion and accelerates wound healing. GelMA\u2010CA is synthesized by modifying gelatin methacryloyl (GelMA) with caffeic acid (CA), while hyaluronic acid methacryloyl (HAMA) is introduced to prepare a double network hydrogel. Silver nitrate is then introduced to make it pH\u2010responsive through the formation of coordination between the polyphenolic structure of caffeic acid and the silver ions. The composite hydrogel exhibited excellent antioxidant properties and strong antimicrobial activity against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Furthermore, the composite hydrogel accelerated the promotion of wound healing in a rat model of S. aureus\u2010infected wounds. In conclusion, the HAMA\/GelMA\u2010CA\/Ag<jats:sup>+<\/jats:sup> hydrogel is a promising bioactive material that can be used as a wound dressing to promote the healing of acutely infected wounds.<\/jats:p>","DOI":"10.1002\/adbi.202400358","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T05:37:11Z","timestamp":1734154631000},"source":"Crossref","is-referenced-by-count":15,"title":["Development of a pH\u2010Responsive Antimicrobial and Potent Antioxidant Hydrogel for Accelerated Wound Healing: A Game Changer in Drug Delivery"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8590-1258","authenticated-orcid":false,"given":"Qixiang","family":"Gui","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital)  Shanghai 200003 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