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This study examines electroacupuncture (EA) effects on cognition, hippocampal pathology, neurotransmitters, and the RAGE\/LRP1 system in senescence\u2010accelerated mouse prone 8 (SAMP8) mice. EA at Zusanli (ST36) and Baihui (GV20) improved cognitive performance, reduced hippocampal neuronal degeneration, elevated cerebrospinal fluid dopamine, norepinephrine, serotonin, and 5\u2010hydroxyindoleacetic acid, and decreased A\u03b242 levels. EA downregulated hippocampal RAGE, vascular cell adhesion molecule\u20101 (VCAM\u20101), and intercellular adhesion molecule\u20101 (ICAM\u20101), upregulated LRP1 and apolipoprotein E (ApoE), promoting A\u03b2 clearance. NF\u2010\u03baB expression remained unchanged, suggesting alternative anti\u2010inflammatory pathways. Thus, EA offers a promising non\u2010pharmacological treatment for ARCI.<\/jats:p>","DOI":"10.1002\/adbi.202400377","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T07:20:23Z","timestamp":1744096823000},"source":"Crossref","is-referenced-by-count":0,"title":["Electroacupuncture's Impact on the Hippocampal RAGE\/LRP1 Receptor System in SAMP8 Mice"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-1938","authenticated-orcid":false,"given":"Zhitao","family":"Hou","sequence":"first","affiliation":[{"name":"College of Basic Medical and Sciences Heilongjiang University of Chinese Medicine  Harbin Heilongjiang 150040 China"},{"name":"Department of Systems Pharmacology and Translational Therapeutics Perelman School of Medicine University of Pennsylvania  Philadelphia PA 19104 USA"},{"name":"Key Laboratory of Chinese Internal Medicine of the Ministry of Education Dongzhimen Hospital Affiliated with Beijing University of 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