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However, ROS can exhibit both tumor\u2010promoting and tumor\u2010suppressing activities in cancers, and exhibit different effects depending on its source\u2014mtROS vs non\u2010mtROS. Additionally, since ROS from different sources possesses distinct functions, mitochondria\u2010targeted antioxidants, and non\u2010targeted antioxidants may have entirely different effects on cancer progression. To address this complexity, novel measurement techniques such as MitoSOX, MitoPY1, and siDMA are used to specifically assess mtROS, providing deeper insights into mitochondrial function during treatment. Therefore, distinguishing the sources of ROS and separately detecting and targeting mtROS and non\u2010mtROS can further clarify the anti\u2010tumor mechanisms of ponicidin and provide a foundation for subsequent research.<\/jats:p>","DOI":"10.1002\/adbi.202400549","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T09:08:45Z","timestamp":1737536925000},"source":"Crossref","is-referenced-by-count":2,"title":["The Role of ROS and Its Sources in Tumorigenesis: Friend or Foe?"],"prefix":"10.1002","volume":"9","author":[{"given":"Qin","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of General Surgery the Second Xiangya Hospital Central South University  Changsha Hunan 410011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of General Surgery Huaihua Second People's Hospital  Huaihua Hunan 418000 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