{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:00:26Z","timestamp":1790089226691,"version":"4.0.1"},"reference-count":97,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Biology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Diabetes mellitus is a chronic metabolic disorder that affects multiple organs, including the stomach. This research examines the effects of naringin and\/or zinc on stomach and pancreatic tissues of streptozotocin\u2010induced diabetic rats. Type 2 diabetes is induced by intraperitoneal injection of nicotinamide and streptozotocin. Three weeks after diabetes induction, rats receive eight weeks of treatment. Malondialdehyde and total antioxidant capacity are estimated colorimetrically. Asprosin and P\u2010selectin levels are assessed via ELISA. Quantitative RT\u2010PCR analysis of nuclear factor kappa B (NF\u2010\u043aB), peroxisome proliferator\u2010activated receptor gamma (PPAR \u03b3), and nuclear factor erythroid 2\u2010related factor 2 (Nrf\u20102) genes is carried out. Tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) is assessed immunohistochemically, and stomach and pancreatic tissues are examined histologically. Combined naringin and zinc treatment significantly reduces gastric Malondialdehyde, serum asprosin, and P\u2010selectin levels in serum, stomach, and pancreas compared to diabetic rats. Additionally, gastric NF\u2010\u043aB expression is significantly lower, while PPAR \u03b3 and Nrf\u20102 expressions are significantly higher compared to diabetic rats. Immunohistochemical analysis and histopathological examination confirm these findings. In conclusion, combined naringin and zinc treatment significantly improves gastric alterations in diabetic rats by reducing oxidative stress and inflammation. Nonetheless, it shows no additional impacts on pancreatic tissue compared to naringin or zinc alone.<\/jats:p>","DOI":"10.1002\/adbi.202400688","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T04:45:14Z","timestamp":1739767514000},"source":"Crossref","is-referenced-by-count":4,"title":["Effects of Naringin and Zinc Treatment on Biochemical, Molecular, and Histological Alterations in Stomach and Pancreatic Tissues of STZ\u2010Induced Diabetic Rats"],"prefix":"10.1002","volume":"9","author":[{"given":"Al\u2010Shimaa M.","family":"Abas","sequence":"first","affiliation":[{"name":"Biochemistry Department Faculty of Science Zagazig University  Zagazig 44519 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed H.","family":"Sherif","sequence":"additional","affiliation":[{"name":"Chemistry Department Faculty of Science Zagazig University  Zagazig 44519 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4541-8343","authenticated-orcid":false,"given":"Sarah","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Biochemistry Department Faculty of Science Zagazig University  Zagazig 44519 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051835"},{"key":"e_1_2_10_2_1","first-page":"23","volume":"2","author":"Mohajan D.","year":"2023","journal-title":"Studies Social Sci. 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