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These models are used to analyze various aspects of the pathology by replicating the conditions of the syndrome. Even though the complexity of polycystic ovary syndrome and the challenge of reproducing all its features leave several questions unanswered, studies conducted to date have elucidated some of the alterations in ovarian follicle molecular and cellular mechanisms involved in the syndrome, and do not require the employment of complex and invasive techniques on human patients. This review examines ovarian functions and their alterations in polycystic ovary syndrome, explores preclinical in vivo and in vitro models, and highlights emerging research and medical perspectives. It targets researchers, healthcare professionals, and academics, including endocrinologists, cell biologists, and reproductive medicine specialists, studying the molecular and cellular mechanisms of the syndrome.<\/jats:p>","DOI":"10.1002\/adbi.202400713","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T09:06:54Z","timestamp":1737536814000},"source":"Crossref","is-referenced-by-count":3,"title":["Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8889-2634","authenticated-orcid":false,"given":"Arturo","family":"Bevilacqua","sequence":"first","affiliation":[{"name":"Department of Dynamic and Clinical Psychology, and Health Studies Sapienza University of Rome  Via Dei Marsi 78 Rome 00185 Italy"},{"name":"The Experts Group on Inositols in Basic and Clinical Research and on PCOS (EGOI\u2010PCOS)  Rome Italy"},{"name":"Systems Biology Group Lab and Research Center in Neurobiology Daniel Bovet (CRiN)  Rome 00185 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0485-2528","authenticated-orcid":false,"given":"Cristiano","family":"Giuliani","sequence":"additional","affiliation":[{"name":"Department of Dynamic and Clinical Psychology, and Health Studies Sapienza University of Rome  Via Dei Marsi 78 Rome 00185 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9442-6923","authenticated-orcid":false,"given":"Giovanna Di","family":"Emidio","sequence":"additional","affiliation":[{"name":"Department of Life Health and Environmental Sciences University of L'Aquila  L'Aquila 67100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9781-2376","authenticated-orcid":false,"given":"Samuel H","family":"Myers","sequence":"additional","affiliation":[{"name":"R&amp;D Department  Lo.Li Pharma s.r.l Rome 00156 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1805-3181","authenticated-orcid":false,"given":"Vittorio","family":"Unfer","sequence":"additional","affiliation":[{"name":"The Experts Group on Inositols in Basic and Clinical Research and on PCOS (EGOI\u2010PCOS)  Rome Italy"},{"name":"UniCamillus\u2010Saint Camillus International University of Health Sciences  Rome 00156 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4978-2571","authenticated-orcid":false,"given":"Carla","family":"Tatone","sequence":"additional","affiliation":[{"name":"Department of Life Health and Environmental Sciences University of L'Aquila  L'Aquila 67100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00163-2"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1494"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:30:1:19"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg440"},{"key":"e_1_2_9_5_1","first-page":"p181","volume":"29","author":"Stein I. 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