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Nevertheless, the conventional anti\u2010osteoporotic medications and hormonal therapeutic regimens currently employed in clinical practice are associated with a multitude of adverse effects, thereby constraining their overall therapeutic efficacy and potential. Recently, nanomaterials have emerged as a promising alternative due to their minimal side effects, efficient drug delivery, and ability to enhance bone formation, aiding in restoring bone balance. This review delves into the fundamental principles of bone remodeling and the bone microenvironment, as well as current clinical treatment approaches for osteoporosis. It subsequently explores the research status of nanomaterial\u2010based drug delivery systems for osteoporosis treatment, encompassing inorganic nanomaterials, organic nanomaterials, cell\u2010mimicking carriers and exosomes mimics and emerging therapies targeting the osteoporosis microenvironment. Finally, the review discusses the potential of nanomedicine in treating osteoporosis and outlines the future trajectory of this burgeoning field. The aim is to provide a comprehensive reference for the application of nanomaterial\u2010based drug delivery strategies in osteoporosis therapy, thereby fostering further advancements and innovations in this critical area of medical research<\/jats:p>","DOI":"10.1002\/adbi.202400721","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T07:31:34Z","timestamp":1744097494000},"source":"Crossref","is-referenced-by-count":6,"title":["Nanomaterials\u2010Based Drug Delivery Systems for Therapeutic Applications in Osteoporosis"],"prefix":"10.1002","volume":"9","author":[{"given":"Donghong","family":"Shi","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Hebei Province Institute of Biophysics School of Health Sciences and Biomedical Engineering, Innovation and Research Institute of Hebei University of Technology in Shijiazhuang Hebei University of Technology  Tianjin 300401 P. R. China"},{"name":"State Key Laboratory of Reliability and Intelligence of Electrical Equipment School of Electrical Engineering Hebei University of Technology  Tianjin 300130 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Hebei Province Institute of Biophysics School of Health Sciences and Biomedical Engineering, Innovation and Research Institute of Hebei University of Technology in Shijiazhuang Hebei University of Technology  Tianjin 300401 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Tian","sequence":"additional","affiliation":[{"name":"Hebei Tourism College  Hebei Chengde 067000 P. R. 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