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Sarcopenia can cause a severe decline in strength and movement, and even lead to prolonged bed rest. Nutritional support is an emerging approach to mitigate sarcopenia and is currently the gold standard for clinical management of sarcopenia. However, complex nutritional composition may affect the effect of treatment. Herein, the pathogenesis of sarcopenia is first introduced. Then, the diagnostic methods of sarcopenia are described in detail, including grip strength, chair stand test, dual\u2010energy X\u2010ray Absorptiometry, bioelectrical impedance analysis, gait speed, balance tests, and biomarkers. Then, the latest progress of the nutritional support (including protein quantity and quality, bioactive peptides, amino acids and their metabolites, antioxidant\/ anti\u2010inflammatory nutrients, vitamins and minerals, microbiome\u2010targeted interventions, metabolite\u2010derived molecules, and Chinese herbal medicine) on the mitigation of sarcopenia is elaborated. This review may contribute to the understanding of the mechanism and importance of diagnosis and nutritional support in alleviating sarcopenia, so as to promote the development of sarcopenia treatment.<\/jats:p>","DOI":"10.1002\/adbi.202500244","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T16:55:19Z","timestamp":1755622519000},"source":"Crossref","is-referenced-by-count":4,"title":["Pathogenesis, Diagnosis Method, and Current Nutritional Support Strategy for Sarcopenia"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2130-847X","authenticated-orcid":false,"given":"Yafei","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biology Zibo Polytechnic University  Zibo 255000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xue","sequence":"additional","affiliation":[{"name":"Inner Mongolia Mengniu Dairy (Group) Co., Ltd  Hohhot 011517 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health China Agricultural University  Beijing 100089 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoya","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102376"},{"key":"e_1_2_10_2_1","volume-title":"Biochemistry and Cell Biology of Ageing: Part IV","author":"Cheng K. 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