{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:59:32Z","timestamp":1785347972250,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Biology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bronchopulmonary dysplasia (BPD), a debilitating chronic respiratory condition afflicting preterm neonates, stems from oxidative injury and is characterized by arrested alveolar growth and aberrant inflammatory responses. This investigation uncovers a novel mechanistic axis in which the 20\u2010hydroxyeicosatetraenoic acid (20\u2010HETE)\/GPR75 signaling cascade acts as a previously unrecognized driver of NLRP1 inflammasome activation in neonatal BPD, thereby linking oxidative stress to inflammatory signaling via p53. Using murine hyperoxia models, we observe that excessive oxygen exposure selectively upregulates GPR75 expression and 20\u2010HETE biosynthesis within alveolar epithelial cells. Genetic inactivation of\n                    <jats:italic>Gpr75<\/jats:italic>\n                    in vivo significantly attenuated hyperoxia\u2010induced lung injury, oxidative stress, and NLRP1\u2010dependent secretion of interleukin\u20101\u03b2 and interleukin\u201018. Mechanistic dissection revealed that 20\u2010HETE induces NLRP1 inflammasome assembly in rat alveolar epithelia via p53\u2010mediated signaling. In vitro corroboration via lentiviral\u2010mediated Gpr75 silencing, with scrambled shRNA serving as a negative control, further validated its role in hyperoxia\u2010triggered NLRP1 activation and cytokine release (P\u00a0&lt; 0.01\u00a0vs. scrambled control). Collectively, these findings establish the 20\u2010HETE\/GPR75 axis as a critical regulator of inflammasome\u2010dependent pathogenesis in BPD. Blockade of this axis inhibits inflammasome assembly and downstream inflammation by suppressing p53 signaling. These results highlight this axis as a promising therapeutic target to mitigate oxygen\u2010induced injury and inflammatory sequelae in preterm infants.\n                  <\/jats:p>","DOI":"10.1002\/adbi.202500321","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:36:51Z","timestamp":1784799411000},"source":"Crossref","is-referenced-by-count":0,"title":["The 20\u2010HETE\/GPR75 Axis Drives NLRP1 Inflammasome Activation via p53 in Bronchopulmonary Dysplasia"],"prefix":"10.1002","volume":"10","author":[{"given":"QiuXiang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Shanxi Children's Hospital  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoLi","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Medicine Shenyang Children's Hospital  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shenyang Children's Hospital  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2805-3485","authenticated-orcid":false,"given":"Jian","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shenyang Children's Hospital  Shenyang 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