{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T06:25:53Z","timestamp":1774851953884,"version":"3.50.1"},"reference-count":120,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203925"],"award-info":[{"award-number":["82203925"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201013"],"award-info":[{"award-number":["82201013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2024JC\u2010YBMS\u2010645"],"award-info":[{"award-number":["2024JC\u2010YBMS\u2010645"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Biology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Stem cells from human exfoliated deciduous teeth (SHED) and their derivatives have emerged as promising therapeutic agents for treating immune\u2010mediated inflammatory diseases (IMIDs). IMIDs are characterized by dysregulated immune responses, leading to chronic inflammation and tissue damage. The current treatment landscape for IMIDs faces challenges, including the complexity of disease mechanisms and the limitations of existing therapies, which frequently fail to achieve long\u2010term remission and are often associated with significant side effects. Consequently, there is a pressing need for innovative therapies that not only alleviate symptoms but also address the underlying immune dysfunction and promote the repair of damaged tissues. In this context, SHED and their derivatives offer a dual therapeutic advantage by harnessing both immunomodulatory and regenerative capacities. Research highlighted in this review demonstrates the therapeutic potential of SHED and their derivatives in multiple IMIDs, such as systemic lupus erythematosus, Sj\u00f6gren's syndrome, multiple sclerosis, and rheumatoid arthritis. Critically, the aim of this review is not only to synthesize recent progress in SHED research for IMID treatment but also to highlight the strategic significance of innovative therapies emerging from the intersection of regenerative medicine and immunology.<\/jats:p>","DOI":"10.1002\/adbi.202500443","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T10:33:08Z","timestamp":1774348388000},"source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Potential of Stem Cells From Human Exfoliated Deciduous Teeth and Their Derivatives in Immune\u2010Mediated Inflammatory Diseases: Mechanisms and Perspectives"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2962-3123","authenticated-orcid":false,"given":"Wenbo","family":"Cui","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Clinical Research Center for Oral Diseases Department of Preventive Dentistry School of Stomatology The Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Stomatology 924th Hospital of Joint Logistics Support Force Chinese People's Liberation Army  Guilin Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anqi","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Clinical Research Center for Oral Diseases Department of Preventive Dentistry School of Stomatology The Fourth Military Medical University  Xi'an China"},{"name":"Department of Dermatology 985th Hospital of Joint Logistics Support Force Chinese People's Liberation Army  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiling","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Clinical Research Center for Oral Diseases Department of Preventive Dentistry School of Stomatology The Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9123-0538","authenticated-orcid":false,"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Clinical Research Center for Oral Diseases Department of Oral Medicine, School of Stomatology The Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Clinical Research Center for Oral Diseases Department of Preventive Dentistry School of Stomatology The Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Dermatology 985th Hospital of Joint Logistics Support Force Chinese People's Liberation Army  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8518-8222","authenticated-orcid":false,"given":"Zhenlai","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Clinical Research Center for Oral Diseases Department of Oral Medicine, School of Stomatology The Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X17666220417153309"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.05.004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.05.006"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202300155"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0937635100"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001312"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2023.103410"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00603-1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1249500"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501457"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0293908"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14776"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1909094"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12061297"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-020-00280-5"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00768-1"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213654"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13101"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14051"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljaf134"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24370"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.06.012"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199447010-00003"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0374-8"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.2315"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-024-01079-8"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.13103"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606910"},{"key":"e_1_2_11_30_1","article-title":"Siponimod for Multiple Sclerosis","volume":"11","author":"Cao L.","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0701-9"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01037-x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2024.10.008"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf3227"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-018-0628-x"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222112018"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-020-09896-3"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5214"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509340867"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2025.105604"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202407446"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X14666191018122109"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8973613"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.02.014"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.10.001"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.06.151"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2015.04.009"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.07.043"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.248"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.07.009"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.125"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba2987"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.07.026"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt5"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042718-041717"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2021.01.006"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03308-y"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13113"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.141578"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.39"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0677-6"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102861"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2016.09.002"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-024-00217-8"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01898-7"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-043021-032611"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224762"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1538-9"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.123463"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27560"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.08.012"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aat1482"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051777"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00634-x"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66990-5"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-024-01135-3"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120278"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.676885"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910474"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00587-3"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.6MA0921-752RR"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002610"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c16595"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4029"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-391144"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.37351"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30481-1"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01473-3"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028936"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.07.051"},{"key":"e_1_2_11_92_1","first-page":"156","article-title":"Clusters of Activated Microglia in Normal\u2010appearing White Matter Show Signs of Innate Immune Activation","volume":"9","author":"Horssen J.","year":"2012","journal-title":"Journal of Neuroinflammation"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02583-y"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a032003"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114674"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25676-2"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20201544"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1177\/2055217318765288"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000928"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c19748"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/stcltm\/szae006"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2018.0016"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01446-1"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.676759"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.04.001"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0648-5"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2017.03.015"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4088-14.2015"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1090"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0096-x"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120225"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040880"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00985-4"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.12.013"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2013.05.008"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.20-0303"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-019-0433-y"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01525-8"},{"key":"e_1_2_11_119_1","article-title":"Rheumatoid Arthritis: Pathogenesis and Therapeutic Advances","volume":"5","author":"Gao Y.","year":"2020","journal-title":"Medical Communications"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.7023"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.07.024"}],"container-title":["Advanced Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.202500443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adbi.202500443","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.202500443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T05:06:05Z","timestamp":1774847165000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adbi.202500443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":120,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/adbi.202500443"],"URL":"https:\/\/doi.org\/10.1002\/adbi.202500443","archive":["Portico"],"relation":{},"ISSN":["2701-0198","2701-0198"],"issn-type":[{"value":"2701-0198","type":"print"},{"value":"2701-0198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"article-number":"e00443"}}