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Understanding the underlying mechanisms of tumor dormancy and reactivation is crucial for developing effective clinical interventions. However, current clinical translation faces multiple challenges, including limitations in detecting dormant tumor cells, insufficient biomarkers for dormancy, and difficulties in targeted drug delivery. Recent advances in elucidating the mechanisms of dormancy\u2014such as the establishment of the pre\u2010metastatic niche, intercellular communication in the bone marrow microenvironment, and signaling pathways regulating dormancy and reactivation\u2014have provided novel therapeutic targets. Based on these mechanistic insights, nanotechnology\u2010based drug delivery systems have emerged as promising strategies to precisely target dormant breast cancer cells in bone marrow niches. In this review, we summarize the current understanding of dormancy mechanisms in breast cancer bone metastasis, discuss the barriers hindering clinical translation, and highlight how mechanism\u2010driven nanotherapeutic strategies may offer new opportunities to prevent recurrence by targeting dormant tumor cells.<\/jats:p>","DOI":"10.1002\/adbi.202500485","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:35:52Z","timestamp":1772980552000},"source":"Crossref","is-referenced-by-count":6,"title":["Dormancy and Recurrence in Breast Cancer Bone Metastasis: From Mechanisms to Clinical Translation"],"prefix":"10.1002","volume":"10","author":[{"given":"Ziqi","family":"Sun","sequence":"first","affiliation":[{"name":"Innovation Research Institute of Traditional Chinese Medicine Shandong University of Traditional Chinese Medicine  Jinan 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