{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:53:08Z","timestamp":1783479188943,"version":"3.55.0"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572547"],"award-info":[{"award-number":["82572547"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Biology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Two recent studies identified feline coronavirus 23 (FCoV\u201023), a recombinant feline coronavirus responsible for severe feline infectious peritonitis outbreaks in Cyprus. Recombination analysis revealed two breakpoints flanking a region spanning ORF1b and the spike gene, sharing 96.5% identity with the hypervirulent canine coronavirus (CCoV) strain NA\/09, with phylogenetic analysis confirming that the FCoV\u201023 spike\u00a0gene clusters with CCoV\u20102 while the genomic backbone clusters with FCoV\u20101. Structurally, conserved receptor binding domain (RBD)\u00a0residues (Y549\/Q551\/W592) enable FCoV\u201023 to recognize aminopeptidase N (APN) across feline, canine, porcine, and avian hosts, while reduced human APN binding results from loss of N739 glycosylation due to a single substitution at position 741. Deletion of the N\u2010terminal domain 0 (D0), present in over 90% of Cyprus cases, enhances cell entry kinetics and promotes macrophage tropism. Comparative analysis with APN\u2010utilizing CoVs, including CCoV\u2010HuPn\u20102018 and HCoV\u2010229E, highlights the zoonotic potential of this CoV lineage and underscores the need for enhanced surveillance and pandemic preparedness.<\/jats:p>","DOI":"10.1002\/adbi.202500513","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:10:37Z","timestamp":1778843437000},"source":"Crossref","is-referenced-by-count":1,"title":["Cross\u2010Species Transmission and Structural Adaptive Evolution: Implications of the FCoV\u201023 Pandemic for the Evolution of Coronaviruses"],"prefix":"10.1002","volume":"10","author":[{"given":"Lili","family":"Tian","sequence":"first","affiliation":[{"name":"College of Life Science and Technology Beijing University of Chemical Technology  Beijing China"},{"name":"School of Life Sciences Tianjin University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4465-8501","authenticated-orcid":false,"given":"Huiyu","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology Beijing University of Chemical Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5007-2158","authenticated-orcid":false,"given":"Huahao","family":"Fan","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology Beijing University of Chemical Technology  Beijing China"},{"name":"School of Life Sciences Tianjin University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009340\u20100"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009155\u2010z"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009007\u2010w"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.05.019"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201004266\u20109"}],"container-title":["Advanced Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.202500513","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adbi.202500513","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.202500513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:58:36Z","timestamp":1783011516000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adbi.202500513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/adbi.202500513"],"URL":"https:\/\/doi.org\/10.1002\/adbi.202500513","archive":["Portico"],"relation":{},"ISSN":["2701-0198","2701-0198"],"issn-type":[{"value":"2701-0198","type":"print"},{"value":"2701-0198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"article-number":"e00513"}}