{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:23:58Z","timestamp":1783013038028,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Biology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bone homeostasis is maintained through balanced interactions between osteoblasts and osteoclasts, whereas chronic inflammation disrupts this balance by enhancing osteoclast activity and bone loss. This study investigated the protective effects of\n                    <jats:italic>Cibotii Rhizoma<\/jats:italic>\n                    (CR) on inflammatory bone destruction and its underlying mechanisms. In vitro, CR suppressed receptor activator of nuclear factor kappa B ligand (RANKL)\u2010induced osteoclastogenesis in bone marrow\u2010derived monocyte\/macrophage (BMM) cultures by downregulating NFATc1, c\u2010Src, and TRAF6, thereby inhibiting osteoclast formation, podosomal actin ring assembly, and cell fusion. In vivo, administration of CR in an LPS\u2010induced bone loss mouse model preserved bone microarchitecture, as confirmed by micro\u2010CT and histological analyses, and significantly reduced osteoclast numbers and calvarial bone erosion. Immunohistochemical staining further revealed decreased RANK and NFATc1 activity in calvarial bone tissue following CR treatment. Collectively, these findings indicate that CR mitigates inflammatory bone loss by targeting RANK signaling to inhibit osteoclastogenesis and bone resorption, highlighting its potential as a therapeutic agent for inflammatory bone diseases.\n                  <\/jats:p>","DOI":"10.1002\/adbi.202500599","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:31:01Z","timestamp":1777876261000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>Cibotii Rhizoma<\/i>\n                    Extract Mitigates LPS\u2010Induced Inflammatory Bone Loss by Inhibiting the RANK Signaling Pathway to Suppress Osteoclastogenesis and Bone Resorption"],"prefix":"10.1002","volume":"10","author":[{"given":"Jin Young","family":"Hong","sequence":"first","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Jin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunseong","family":"Kim","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junseon","family":"Lee","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhwan","family":"Yeo","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5020-6723","authenticated-orcid":false,"given":"In\u2010Hyuk","family":"Ha","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3669"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9092073"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2022.116540"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2022.101780"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-023-00824-4"},{"key":"e_1_2_12_7_1","first-page":"345","article-title":"Receptor Activator of Nuclear Factor\u2010\u03baB Ligand and Osteoprotegerin: Maintaining the Balance to Prevent Bone Loss","volume":"5","author":"Trouvin A. P.","year":"2010","journal-title":"Clinical interventions in aging"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2005.11.007"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36809"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.07.017"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/np9004097"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914798"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-141"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.4068\/cmj.2016.52.1.12"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.02.015"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2007-0237"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0285-4"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(03)00201-1"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.08.005"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.478545"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115895"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114761"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114101"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105109"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.05.008"},{"key":"e_1_2_12_26_1","first-page":"232","article-title":"Protocatechuic Acid Attenuates Anterior Cruciate Ligament Transection\u2010Induced Osteoarthritis by Suppressing Osteoclastogenesis","volume":"19","author":"Zhang J.","year":"2020","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5565"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.754088"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7280342"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.5397\/cise.2021.00395"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115732"}],"container-title":["Advanced Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.202500599","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adbi.202500599","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.202500599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:58:52Z","timestamp":1783011532000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adbi.202500599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/adbi.202500599"],"URL":"https:\/\/doi.org\/10.1002\/adbi.202500599","archive":["Portico"],"relation":{},"ISSN":["2701-0198","2701-0198"],"issn-type":[{"value":"2701-0198","type":"print"},{"value":"2701-0198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"article-number":"e00599"}}