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It is characterized by jawbone necrosis, infection, and impaired bone healing, severely affecting the patient's quality of life. Although the pathogenesis of MRONJ has been extensively studied, the exact pathophysiological process remains unclear. The currently accepted mechanisms include inhibition of bone formation, inhibition of angiogenesis, and oral microbial infection, which interact to form a vicious cycle, further exacerbating disease progression. This review explores the effects of anti\u2010resorptive and anti\u2010angiogenic drugs on MRONJ, the role of microbial infection in disease development, current non\u2010surgical and surgical treatment strategies, and future research directions, aiming to provide references for clinical diagnosis and treatment as well as research.<\/jats:p>","DOI":"10.1002\/adbi.202500627","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:53:27Z","timestamp":1769604807000},"source":"Crossref","is-referenced-by-count":1,"title":["Progress in Research on Medication\u2010Related Osteonecrosis of the Jaw: From Pathophysiological Mechanisms to Clinical Treatment"],"prefix":"10.1002","volume":"10","author":[{"given":"Xinliang","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Jilin University  Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Jilin University  Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichen","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Jilin University  Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Jilin University  Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzi","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Jilin University  Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Jilin University  Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifu","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Jilin University  Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9598-3331","authenticated-orcid":false,"given":"Zilin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Jilin University  Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"issue":"2","key":"e_1_2_12_2_1","article-title":"Medication\u2010Related Osteonecrosis of the Jaw: A Review","volume":"12","author":"Aldhalaan N. 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