{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:19:36Z","timestamp":1787804376257,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016756","name":"Kempe Foundation","doi-asserted-by":"publisher","award":["JCK22\u20100003"],"award-info":[{"award-number":["JCK22\u20100003"]}],"id":[{"id":"10.13039\/100016756","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Biology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The purpose was to investigate whether the eosinophil biomarker EMR1, ectopically expressed in colon cancer tumor cells, could be used to identify patients at risk for relapse after curative surgery. EMR1 mRNA levels were determined in primary tumors (\n                    <jats:italic>n<\/jats:italic>\n                    = 66) and lymph nodes (LNs;\n                    <jats:italic>n<\/jats:italic>\n                    = 377) from 121 colon cancer patients. Controls were resection margins of colon cancer tumors and LNs from patients with inflammatory bowel disease. Primary read\u2010out was recurrency evaluated as disease\u2010free survival time in the Kaplan\u2013Meier survival model and hazard ratio calculation by uni\u2010 and multivariate Cox regression. High EMR1 levels in the regional LNs were associated with poor prognosis [hazard ratio 3.1 (1.2\u20138.0) at 5\u2010year follow\u2010up,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.02]. Patients with a very poor prognosis were identified by combining EMR1 with CXCL17 analysis of LNs [hazard ratio 4.6 (1.1\u201319.7),\n                    <jats:italic>p<\/jats:italic>\n                    = 0.04]. High EMR1 levels in the primary tumor were associated with a good prognosis [hazard ratio 0.1 (0.02\u20130.9),\n                    <jats:italic>p<\/jats:italic>\n                    = 0.04]. Multivariate analysis strengthened the result for LNs but weakened the result for the primary tumor. These contradictory prognostic results probably relate to the prominent eosinophilia in the primary tumor, essentially lacking in LNs, where ectopically expressed EMR1 in tumor cells dominates. Thus, EMR1 expressed in tumor cells probably promotes tumor growth.\n                  <\/jats:p>","DOI":"10.1002\/adbi.202500645","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:38:16Z","timestamp":1786700296000},"source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Role of EMR1 in Lymph Nodes and Primary Tumors of Colon Cancer Patients"],"prefix":"10.1002","volume":"10","author":[{"given":"Tamer","family":"Roshdy","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology Ume\u00e5 University  Ume\u00e5 Sweden"},{"name":"Department of Diagnostics and Intervention, Oncology Ume\u00e5 University  Ume\u00e5 Sweden"},{"name":"Department of Molecular Biology, Genetic Engineering, and Biotechnology Research Institute University of Sadat City  Sadat City Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagar","family":"Eltorky","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Ume\u00e5 University  Ume\u00e5 Sweden"},{"name":"Department of Diagnostics and Intervention, Oncology Ume\u00e5 University  Ume\u00e5 Sweden"},{"name":"Department of Biochemistry Faculty of Science Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Ume\u00e5 University  Ume\u00e5 Sweden"},{"name":"Department of Diagnostics and Intervention, Oncology Ume\u00e5 University  Ume\u00e5 Sweden"},{"name":"Department of Biochemistry Faculty of Science Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faten","family":"Zahran","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Science Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Guirgis","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Genetic Engineering, and Biotechnology Research Institute University of Sadat City  Sadat City Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Olsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Lindmark","sequence":"additional","affiliation":[{"name":"Institution of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Louise","family":"Hammarstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sten","family":"Hammarstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8803-4798","authenticated-orcid":false,"given":"Basel","family":"Sitohy","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Ume\u00e5 University  Ume\u00e5 Sweden"},{"name":"Department of Diagnostics and Intervention, Oncology Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Global Cancer Observatory Cancer Today Accessed February 8 2024 https:\/\/gco.iarc.fr\/."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010197"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2017.06.010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v15.i4.495"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2014.975839"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24585"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14061474"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.42"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100142(20000401)88:7<1544::AID\u2010CR7>3.3.CO;2\u2010J"},{"issue":"6","key":"e_1_2_10_13_1","first-page":"2997","article-title":"Eosinophil Infiltration of human Colonic Carcinomas as a Prognostic Indicator","volume":"43","author":"Pretlow T. 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