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Hypoxia\u2010inducible microRNA\u2010210 (miR\u2010210) has emerged as a central mediator of cellular adaptation to oxygen deprivation and ischemic injury. As a prototypical \u201chypoxamir,\u201d miR\u2010210 regulates metabolic reprogramming, apoptosis, angiogenesis, and vascular remodeling, thereby influencing disease onset, progression, and repair. Its expression is governed by transcription factors, while downstream targets modulate mitochondrial function, DNA repair, and apoptotic signaling. Functionally, miR\u2010210 enhances cardiomyocyte survival, promotes endothelial migration and tube formation, attenuates fibrosis, and supports stem cell adaptation. Clinical studies reveal that circulating and exosomal miR\u2010210 correlate with infarct size, collateral formation, and prognosis, suggesting biomarker potential. Preclinical evidence further highlights therapeutic applications through mimics, antagomirs, nanoparticles, and stem cell\u2013derived exosomes, though delivery and safety challenges remain. This review aims to synthesize current knowledge on the regulatory network and functional roles of miR\u2010210 in ischemic cardiovascular disease, and to evaluate its prospects as both a biomarker and a therapeutic target.<\/jats:p>","DOI":"10.1002\/adbi.202500653","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:14:13Z","timestamp":1779113653000},"source":"Crossref","is-referenced-by-count":0,"title":["miR\u2010210 in Ischemic Cardiovascular Disease: Functions, Mechanisms, and Therapeutic Potential"],"prefix":"10.1002","volume":"10","author":[{"given":"Wanqiu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Shandong Provincial Key Medical and Health Laboratory of Endocrinology and Metabolic Diseases Affiliated Hospital of Shandong Second Medical University  Weifang China"},{"name":"Clinical Research Center Affiliated Hospital of Shandong Second Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shandong Provincial Key Medical and Health Laboratory of Endocrinology and Metabolic Diseases Affiliated Hospital of Shandong Second Medical University  Weifang China"},{"name":"Clinical Research Center Affiliated Hospital of Shandong Second Medical University  Weifang China"},{"name":"Department of Endocrinology and Metabolism Tongji Hospital School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Ma","sequence":"additional","affiliation":[{"name":"Clinical Research Center Affiliated Hospital of Shandong Second Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghui","family":"Tian","sequence":"additional","affiliation":[{"name":"Clinical Research Center Affiliated Hospital of Shandong Second Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxia","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shandong Provincial Key Medical and Health Laboratory of Endocrinology and Metabolic Diseases Affiliated Hospital of Shandong Second Medical University  Weifang China"},{"name":"Clinical Research Center Affiliated Hospital of Shandong Second Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shandong Provincial Key Medical and Health Laboratory of Endocrinology and Metabolic Diseases Affiliated Hospital of Shandong Second Medical University  Weifang China"},{"name":"Clinical Research Center Affiliated Hospital of Shandong Second Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7775-2823","authenticated-orcid":false,"given":"Xiaodong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shandong Provincial Key Medical and Health Laboratory of Endocrinology and Metabolic Diseases Affiliated Hospital of Shandong Second Medical University  Weifang China"},{"name":"Clinical Research Center Affiliated Hospital of Shandong Second Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.118.005375"},{"issue":"9","key":"e_1_2_13_3_1","first-page":"e139","article-title":"Report From the American Heart Association","volume":"141","author":"Virani S. 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