{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:59:34Z","timestamp":1785347974798,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["yzjj2024qn29"],"award-info":[{"award-number":["yzjj2024qn29"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Biology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Irreversible and extensive pulmonary fibrosis caused by paraquat (PQ) poisoning is the main cause of death induced by PQ poisoning in developing countries. Studies have confirmed that epithelial\u2010mesenchymal transition (EMT) contributes to the process of pulmonary interstitial fibrosis caused by PQ poisoning. Many studies have proved that a variety of miRNAs are involved in the occurrence and development of EMT. Through animal and cell experiments, we established the model of EMT on mouse lung and MLE\u201012 cell. We found that the expression of Regulator of G\u2010protein signaling 2 (RGS2) was decreased in mice lung tissue and MLE\u201012 induced by PQ, and over\u2010expressed\/inhibited miR\u20109\u20108974\u20105p can decrease\/increase the level of RGS2. We found that pirfenidone (PFD) can relieve PQ\u2010induced EMT in mice lung tissue and MLE\u201012 cells. Meanwhile, we found that it had high expression of RGS2 in PFD group. Mimic\/inhibited miR\u20109\u20108974\u20105p can aggravate or relieve the EMT with decreasing \/increasing the level of RGS2. In conclusion, miR\u20109\u20108974\u20105p can mediate the pulmonary EMT induced by PQ by regulating RGS2.\u00a0PFD exerts a potential therapeutic effect on PQ\u2010induced pulmonary EMT by regulating miR\u20109\u20108974\u20105p\/RGS2 expression.<\/jats:p>","DOI":"10.1002\/adbi.202500680","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:29:04Z","timestamp":1783607344000},"source":"Crossref","is-referenced-by-count":0,"title":["Pirfenidone Ameliorates Paraquat\u2010Induced Epithelial\u2010Mesenchymal Transition via miR\u20109\u20108974\u20105p\/RGS2 Axis"],"prefix":"10.1002","volume":"10","author":[{"given":"Ping","family":"Wang","sequence":"first","affiliation":[{"name":"Emergency Department Zhujiang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehai","family":"An","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Southern Medical 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