{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:19:37Z","timestamp":1787804377244,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Biology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bone fracture healing requires coordinated osteoclast\u2010mediated resorption and osteoblast\u2010driven formation.\n                    <jats:italic>Saposhnikovia divaricata<\/jats:italic>\n                    Schischkin (SDS) is a traditional East Asian medicine with anti\u2010inflammatory and immunomodulatory activities, but its role in bone regeneration remains unclear. This study evaluated the osteogenic potential of SDS using integrated in vitro, in vivo, and in silico approaches. Mouse\u2010derived osteoblasts were treated with SDS, and cell viability, alkaline phosphatase (ALP) activity, and mineralization were assessed by CCK\u20108, ALP assay, and Alizarin Red O staining. A femoral drill\u2010hole injury model was established in C57BL\/6 mice, followed by oral administration of SDS (100, 200, or 400\u00a0mg\/kg). Bone healing was evaluated by micro\u2010computed tomography and histological analyses. SDS enhanced osteoblast viability, ALP activity, mineral deposition, and osteogenic marker expression in vitro. In vivo, SDS increased bone volume fraction and bone mineral density at 1 week after injury, accompanied by reduced TRAP\u2010positive osteoclasts and increased osteocalcin staining. Molecular docking predicted favorable interactions between major chromone\u2010derived constituents of SDS and the bone\u2010related proteins RUNX2 and RANK. Collectively, these findings suggest that SDS may promote cellular processes associated with early bone repair and warrant further investigation into its mechanisms and long\u2010term therapeutic potential.\n                  <\/jats:p>","DOI":"10.1002\/adbi.70149","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:36:16Z","timestamp":1786700176000},"source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Osteoinductive Potential of\n                    <i>Saposhnikovia divaricata<\/i>\n                    Schischkin in a Mouse Drill\u2010Hole Bone Defect Model"],"prefix":"10.1002","volume":"10","author":[{"given":"Hyunseong","family":"Kim","sequence":"first","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Young","family":"Hong","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhwan","family":"Yeo","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Jin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junseon","family":"Lee","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5020-6723","authenticated-orcid":false,"given":"In\u2010Hyuk","family":"Ha","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"308","article-title":"The Bone Remodelling Cycle","volume":"55","author":"Bolamperti S.","year":"2022","journal-title":"Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563218759371"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.02.020"},{"key":"e_1_2_11_5_1","first-page":"233","article-title":"Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement","author":"Siddiqui J. A.","year":"2016","journal-title":"Physiology (Bethesda)"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-024-07059-8"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1522821"},{"key":"e_1_2_11_8_1","first-page":"73","article-title":"Parathyroid Hormone and Its Analogues\u2013Molecular Mechanisms of Action and Efficacy in Osteoporosis Therapy","volume":"62","author":"Misiorowski W.","year":"2011","journal-title":"Endokrynologia Polska"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114147"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-025-01494-4"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.56986\/pim.2024.02.002.http:\/\/www.integrmed.org\/journal\/view.php?number=35"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1423555"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X24500393"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-020-3091-x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(17)30042-0"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112517"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1984238"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2023.100998"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.05.023"},{"key":"e_1_2_11_20_1","first-page":"227","article-title":"Anti\u2010Proliferative and Antioxidant Activities of Saposhnikovia divaricata","volume":"18","author":"Tai J.","year":"2007","journal-title":"Oncology Reports"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.159"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2005.11.007"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-025-00853-6"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.04.014"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.912042"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.882924"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prmcm.2023.100232"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.880988"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.724256"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20194230"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2022.105112"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2018.232"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.12659\/msmbr.901142"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041430304"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.03.014"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3185"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c00771"},{"key":"e_1_2_11_38_1","doi-asserted-by":"crossref","unstructured":"Nikita G.Singh andS.Chaudhary \u201cChromone a Versatile Moiety for Bioactive Lead Molecules \u201d inAIP Conference Proceedings(2023).","DOI":"10.1063\/5.0162956"}],"container-title":["Advanced Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.70149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adbi.70149","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.70149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:07:14Z","timestamp":1787803634000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adbi.70149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/adbi.70149"],"URL":"https:\/\/doi.org\/10.1002\/adbi.70149","archive":["Portico"],"relation":{},"ISSN":["2701-0198","2701-0198"],"issn-type":[{"value":"2701-0198","type":"print"},{"value":"2701-0198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"article-number":"e70149"}}