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Despite their importance in regulating various processes within skeletal muscle, little is known about the role of muscle\u2010resident fibro\u2010adipogenic progenitors (FAPs) in promoting microvascular angiogenesis. In order to better understand the effects of FAPs on angiogenesis, FAPs were co\u2010cultured with adipose\u2010derived microvascular fragments (MVFs) in three\u2010dimensional fibrin hydrogels. We further tested if pre\u2010culturing FAPs in brown adipogenic induction media (BAM) influences their ability to promote MVF angiogenesis. MVFs co\u2010cultured with control FAPs or BAM FAPs for 5 days exhibit robust microvascular network formation with significantly increased vessel percentage area and average vessel length compared to MVFs alone. FAPs cultured in BAM prior to co\u2010culture with MVFs alter vascular network development compared to MVFs co\u2010cultured with control FAPs by significantly increasing average vessel length. Collectively, these results indicate that FAPs are key regulators of microvascular angiogenesis and that BAM FAPs have an improved capacity to promote increases in average vessel length. The current findings support the transplantation of FAPs and MVFs and modulation of FAP pro\u2010angiogenic properties as potential therapeutic approaches for enhancing skeletal muscle angiogenesis in the context of injury and disease.<\/jats:p>","DOI":"10.1002\/adbi.70162","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:02:56Z","timestamp":1792126976000},"source":"Crossref","is-referenced-by-count":0,"title":["Fibro\u2010Adipogenic Progenitors From Skeletal Muscle Enhance Microvascular Angiogenesis in a 3D Model"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-7979","authenticated-orcid":false,"given":"Christian M.","family":"Mendiondo","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering and Chemical Engineering UT San Antonio  San Antonio Texas USA"},{"name":"UT San Antonio Joint Graduate Program in Biomedical Engineering UT San Antonio  San Antonio Texas 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