{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:45:14Z","timestamp":1792129514867,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Biology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The spike (S) protein plays a pivotal role in the invasion of host cells by SARS\u2010CoV\u20102 (COVID\u201019). However, the underlying mechanism of spike protein interaction with host cells remains elusive. Here, it was found that human amniotic epithelial stem cells (HuAECs)\u2010derived exosomes were able to mitigate the cell cycle arrest and lesions of human type II alveolar epithelial primary cells (hAEPC\u2010II) in vitro induced by SARS\u2010CoV\u20102 S protein. Mechanistically, HuAECs transfered\n                    <jats:italic>SENP<\/jats:italic>\n                    mRNA to hAEPC\u2010II by releasing exosomes, induced FGF9 protein deSUMOylation and stimulated its expression in hAEPC\u2010II. Silencing endogenous\n                    <jats:italic>SENP3<\/jats:italic>\n                    mRNA in HuAECs using siRNA weakens the protective effect of HuAECs\u2010derived exosomes on hAEPC\u2010II. Meanwhile, HuAEC\u2010derived exosomes significantly improved lung tissue damage, inflammatory and fibrosis symptoms of humanized hACE2\n                    <jats:sup>KI\/KI<\/jats:sup>\n                    transgenic mice treated to S protein in vivo. In conclusion, this study reveals a novel mechanism by which HuAECs transfered\n                    <jats:italic>SENP<\/jats:italic>\n                    mRNA to hAEPC\u2010II by releasing exosomes and attenuate the lesion of hAEPC\u2010II induced by SARS\u2010CoV\u20102 spike protein.\n                  <\/jats:p>","DOI":"10.1002\/adbi.70163","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:58:01Z","timestamp":1792126681000},"source":"Crossref","is-referenced-by-count":0,"title":["Amniotic Epithelial Stem Cells\u2010Derived Exosomes Attenuate the Lesion of Alveolar Epithelial Cells Induced by SARS\u2010CoV\u20102 Spike Protein via SENP3\u2010 Triggered FGF9 deSUMOylation"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5961-9639","authenticated-orcid":false,"given":"Zeyu","family":"Cui","sequence":"first","affiliation":[{"name":"Shanghai Geriatric Institute of Chinese Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8001-153X","authenticated-orcid":false,"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchen","family":"Lai","sequence":"additional","affiliation":[{"name":"Shanghai Geriatric Institute of Chinese Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3976-3489","authenticated-orcid":false,"given":"Te","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Geriatric Institute of Chinese Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3878-6275","authenticated-orcid":false,"given":"Fangfang","family":"Dou","sequence":"additional","affiliation":[{"name":"Shanghai Geriatric Institute of Chinese Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0646-5971","authenticated-orcid":false,"given":"Lian","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Geriatric Institute of Chinese Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine &amp; Prenatal Diagnosis Center School of Medicine Shanghai First Maternity and Infant Hospital Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.63329"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.04.026"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102665\u20102"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.037"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001368\u2010w"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3695848"},{"issue":"6478","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The Biology, Function, and Biomedical Applications of Exosomes","volume":"367","author":"Kalluri R.","year":"2020","journal-title":"Science"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.7150\/thno.21945","article-title":"Exosome theranostics: Biology and translational medicine","volume":"8","author":"He C.","year":"2018","journal-title":"Theranostics"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13512"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2011.0715"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010019\u20100504\u20106"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2020.151682"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1098461"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01664\u201022"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4FO03468F"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010020\u201001866\u20106"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030587"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015\u2010023\u201010675\u20102"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010021\u201002840\u20103"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2020.0080"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015\u2010022\u201010398\u2010w"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.05.005"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2021.115425"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12933"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3528"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010021\u201003478\u20101"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201015055\u20109"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.38553"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201020\u20104048"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010023\u201001175\u20104"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106953"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204333"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.249771"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.12.024"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103386"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201005676\u20106"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.02.002"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.071431"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.6.2273\u20102287.2005"},{"key":"e_1_2_10_41_1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41580-022-00500-y","article-title":"Signalling Mechanisms and Cellular Functions of SUMO","volume":"23","author":"Vertegaal A. C. O.","year":"2022","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.07.027"}],"container-title":["Advanced Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.70163","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adbi.70163","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adbi.70163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:58:03Z","timestamp":1792126683000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adbi.70163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/adbi.70163"],"URL":"https:\/\/doi.org\/10.1002\/adbi.70163","archive":["Portico"],"relation":{},"ISSN":["2701-0198","2701-0198"],"issn-type":[{"value":"2701-0198","type":"print"},{"value":"2701-0198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"article-number":"e70163"}}