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Hybrids containing different amounts of iron oxide are synthesized by in situ generation. Physicochemical characterisations reveal the presence of superparamagnetic iron oxide nanoparticles (SPION) granted the magnetic properties of the hybrids. Further comprehensive examinations including high resolution transmission electron microscopy (HRTEM), fast Fourier transform simulations, X\u2010ray diffraction, and X\u2010ray photoelectron spectroscopy assure the conformation of prepared SPION as \u03b3\u2010Fe<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>. High r<jats:sub>2<\/jats:sub> relaxivities are obtained in both phantom and in vivo MRI compared to the clinically approved SPION Endorem. The hybrids are successfully radio labeled with technetium\u201099m through a functionalized bisphosphonate and enable SPECT\/CT imaging and \u03b3\u2010scintigraphy to quantitatively analyze the biodistribution in mice. No abnormality is found by histological examination and the presence of SPION and MWNT are identified by Perls stain and Neutral Red stain, respectively. TEM images of liver and spleen tissues show the co\u2010localization of SPION and MWNTs within the same intracellular vesicles, indicating the in vivo stability of the hybrids after intravenous injection. The results demonstrate the capability of the present SPION\u2013MWNT hybrids as dual MRI and SPECT contrast agents for in vivo use.<\/jats:p>","DOI":"10.1002\/adfm.201302892","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T10:43:25Z","timestamp":1384857805000},"page":"1880-1894","source":"Crossref","is-referenced-by-count":83,"title":["Magnetically Decorated Multiwalled Carbon Nanotubes as Dual MRI and SPECT Contrast Agents"],"prefix":"10.1002","volume":"24","author":[{"given":"Julie Tzu\u2010Wen","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Science King's College London  London SE1 9NH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cabana","sequence":"additional","affiliation":[{"name":"Institut de Ci\u00e8ncia de Materials de Barcelona (ICMAB\u2010CSIC) Campus UAB  08193 Bellaterra Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Bourgognon","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science King's College London  London SE1 9NH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houmam","family":"Kafa","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science King's College London  London SE1 9NH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Protti","sequence":"additional","affiliation":[{"name":"Division of Imaging Sciences and Biomedical Engineering King's College London  St. Thomas' Hospital London SE1 7EH UK"},{"name":"Cardiovascular Division, James Black Centre King's College London British Heart Foundation Centre of Excellence  London SE5 9NU UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerrie","family":"Venner","sequence":"additional","affiliation":[{"name":"UCL Institute of Neurology University College London  London WC1N 3BG UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay M.","family":"Shah","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, James Black Centre King's College London British Heart Foundation Centre of Excellence  London SE5 9NU UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane K.","family":"Sosabowski","sequence":"additional","affiliation":[{"name":"Centre for Molecular Oncology, Barts Cancer Institute Queen Mary University of London  London EC1A 7BE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Mather","sequence":"additional","affiliation":[{"name":"Centre for Molecular Oncology, Barts Cancer Institute Queen Mary University of London  London EC1A 7BE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Roig","sequence":"additional","affiliation":[{"name":"Institut de Ci\u00e8ncia de Materials de Barcelona (ICMAB\u2010CSIC) Campus UAB  08193 Bellaterra Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxing","family":"Ke","sequence":"additional","affiliation":[{"name":"Electron Microscopy for Materials Research (EMAT) University of Antwerp  Groenenborgerlaan 171 B\u20102020 Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustaaf","family":"Van Tendeloo","sequence":"additional","affiliation":[{"name":"Electron Microscopy for Materials Research (EMAT) University of Antwerp  Groenenborgerlaan 171 B\u20102020 Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael T. 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