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The infarct cavity is an ideal location for transplantation as it is directly adjacent to the highly plastic peri\u2010infarct region. Direct transplantation of cells near the infarct cavity has resulted in low cell viability. Here, neural progenitor cells derived from induce pluripotent stem cells (iPS\u2010NPC) are delivered to the infarct cavity of stroked mice encapsulated in a hyaluronic acid hydrogel matrix to protect the cells. To improve the overall viability of transplanted cells, each step of the transplantation process is optimized. Hydrogel mechanics and cell injection parameters are investigated to determine their effects on the inflammatory response of the brain and cell viability, respectively. Using parameters that balanced the desire to keep surgery invasiveness minimal and cell viability high, iPS\u2010NPCs are transplanted to the stroke cavity of mice encapsulated in buffer or the hydrogel. While the hydrogel does not promote stem cell survival one week post\u2010transplantation, it does promote differentiation of the neural progenitor cells to neuroblasts.<\/jats:p>","DOI":"10.1002\/adfm.201401483","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T10:29:41Z","timestamp":1410344981000},"page":"7053-7062","source":"Crossref","is-referenced-by-count":173,"title":["Delivery of iPS\u2010NPCs to the Stroke Cavity within a Hyaluronic Acid Matrix Promotes the Differentiation of Transplanted Cells"],"prefix":"10.1002","volume":"24","author":[{"given":"Jonathan","family":"Lam","sequence":"first","affiliation":[{"name":"University of California, Los Angeles Biomedical Engineering Department  420 Westwood Plaza Los Angeles CA 90095 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Lowry","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles Department of Molecular Cell and Developmental Biology  621 Charles Young Dr. Los Angeles CA 90095 USA"},{"name":"University of California, Los Angeles Eli and Edythe Broad Center for Regenerative Medicine  621 Charles Young Dr. Los Angeles CA 90095 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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