{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:33:06Z","timestamp":1793658786031,"version":"4.5.1"},"reference-count":46,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T00:00:00Z","timestamp":1555632000000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000774","name":"Defense Threat Reduction Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA200574"],"award-info":[{"award-number":["R01CA200574"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Funct Materials"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The recent emergence of biomimetic nanotechnology has facilitated the development of next\u2010generation nanodelivery systems capable of enhanced biointerfacing. In particular, the direct use of natural cell membranes can enable multivalent targeting functionalities. Herein, this study reports on the remote loading of small molecule therapeutics into cholesterol\u2010enriched platelet membrane\u2010derived vesicles for disease\u2010targeted delivery. Using this approach, high loading yields for two model drugs, doxorubicin and vancomycin, are achieved. Leveraging the surface markers found on platelet membranes, the resultant nanoformulations demonstrate natural affinity toward both breast cancer cells and methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    . In vivo, this translates to improved disease targeting, increasing the potency of the encapsulated drug payloads compared with free drugs and the corresponding nontargeted nanoformulations. Overall, this work demonstrates that the remote loading of drugs into functional platelet membrane\u2010derived vesicles is a facile means of fabricating targeted nanoformulations, an approach that can be easily generalized to other cell types in the future.\n                  <\/jats:p>","DOI":"10.1002\/adfm.201801032","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T13:11:38Z","timestamp":1524143498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Remote\u2010Loaded Platelet Vesicles for Disease\u2010Targeted Delivery of Therapeutics"],"prefix":"10.1002","volume":"28","author":[{"given":"Man","family":"Ying","sequence":"first","affiliation":[{"name":"Department of NanoEngineering and Moores Cancer Center University of California San Diego  La Jolla CA 92093 USA"},{"name":"Department of Pharmaceutics School of Pharmacy Fudan University, and Key Laboratory of Smart Drug Delivery (Fudan University) Ministry of Education  Shanghai 201203 P. 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