{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:30:24Z","timestamp":1791016224658,"version":"4.1.0"},"reference-count":75,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100013111","name":"Materials Research Science and Engineering Center, Harvard University","doi-asserted-by":"publisher","award":["NSF DMR\u20101720139"],"award-info":[{"award-number":["NSF DMR\u20101720139"]}],"id":[{"id":"10.13039\/100013111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL117326"],"award-info":[{"award-number":["R01HL117326"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL139001"],"award-info":[{"award-number":["R01HL139001"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000183","name":"Army Research Office","doi-asserted-by":"publisher","award":["W911NF\u201017\u20101\u20100326"],"award-info":[{"award-number":["W911NF\u201017\u20101\u20100326"]}],"id":[{"id":"10.13039\/100000183","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000183","name":"Army Research Office","doi-asserted-by":"publisher","award":["W911NF\u201015\u20101\u20100568"],"award-info":[{"award-number":["W911NF\u201015\u20101\u20100568"]}],"id":[{"id":"10.13039\/100000183","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000181","name":"Air Force Office of Scientific Research","doi-asserted-by":"publisher","award":["FA9550\u201016\u20101\u20100150"],"award-info":[{"award-number":["FA9550\u201016\u20101\u20100150"]}],"id":[{"id":"10.13039\/100000181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Funct Materials"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A simple strategy for generating stimuli\u2010responsive peptide\u2010based hydrogels via charge\u2010conversion of a self\u2010assembling peptide (SAP) is described. These materials are formulated as soluble, polyanionic peptides, containing maleic acid, citraconic acid, or dimethylmaleic acid amide masking groups on each lysine residue, which do not form assemblies, but instead flow easily through high gauge needles and catheters. Acid\u2010induced mask hydrolysis renews the zwitterionic nature of the peptides with concomitant and rapid self\u2010assembly via \u03b2\u2010sheet formation into rehealable hydrogels. The use of different masks enables one to tune pH responsiveness and assembly kinetics. In anticipation of their potential for in vivo hydrogel delivery and use, progelators exhibit hemocompatibility in whole human blood, and their peptide components are shown to be noncytotoxic. Finally, demonstration of stimuli\u2010induced self\u2010assembly for dye sequestration suggests a simple, non\u2010covalent strategy for small molecule encapsulation in a degradable scaffold. In summary, this simple, scalable masking strategy allows for preparation of responsive, dynamic self\u2010assembling biomaterials. This work sets the stage for implementing biodegradable therapeutic hydrogels that assemble in response to physiological, disease\u2010relevant states of acidosis.<\/jats:p>","DOI":"10.1002\/adfm.202007733","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T17:38:53Z","timestamp":1610732333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["pH\u2010Responsive Charge\u2010Conversion Progelator Peptides"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-6208","authenticated-orcid":false,"given":"Andrea S.","family":"Carlini","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry University of California San Diego  9500 Gilman Drive La Jolla CA 92093 USA"},{"name":"Department of Chemistry International Institute for Nanotechnology Chemistry of Life Processes Institute and Simpson Querrey Institute Northwestern University  2145 Sheridan Rd Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8305-9133","authenticated-orcid":false,"given":"Wonmin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Chemistry International Institute for Nanotechnology Chemistry of Life Processes Institute and Simpson Querrey Institute Northwestern University  2145 Sheridan Rd Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9210-3493","authenticated-orcid":false,"given":"Naneki C.","family":"McCallum","sequence":"additional","affiliation":[{"name":"Department of Chemistry International Institute for Nanotechnology Chemistry of Life Processes Institute and Simpson Querrey Institute Northwestern University  2145 Sheridan Rd Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9945-5475","authenticated-orcid":false,"given":"Nathan C.","family":"Gianneschi","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of California San Diego  9500 Gilman Drive La Jolla CA 92093 USA"},{"name":"Department of Chemistry International Institute for Nanotechnology Chemistry of Life Processes Institute and Simpson Querrey Institute Northwestern University  2145 Sheridan Rd Evanston IL 60208 USA"},{"name":"Department of Materials Science and Engineering Department of Biomedical Engineering, and Pharmacology Northwestern University  2145 Sheridan Rd Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00221051"},{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1120679"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/b804953j"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883911514533866"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.5b02749"},{"key":"e_1_2_6_3_2","unstructured":"b)J. B. T.Schlenoff Florida State University Research Foundation Inc. Tallahassee FL USA2012 https:\/\/www.freepatentsonline.com\/y2012\/0148522.html."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja071090b"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201300178"},{"key":"e_1_2_6_4_3","doi-asserted-by":"publisher","DOI":"10.1021\/bm501290t"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep06064"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S144452"},{"key":"e_1_2_6_5_3","doi-asserted-by":"publisher","DOI":"10.7150\/thno.18607"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7OB02188G"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.03.057"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200605254"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200800963"},{"key":"e_1_2_6_7_3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.200900825"},{"key":"e_1_2_6_7_4","doi-asserted-by":"publisher","DOI":"10.1021\/nn101638u"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc2900"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn260"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.272.5.H2071"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453676908989529"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140407"},{"key":"e_1_2_6_10_3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.50.2.124"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00086.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-003-0554-x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.426254"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005503"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201800079"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2011.0077"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1215263"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA16912G"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4294"},{"key":"e_1_2_6_16_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b08165"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30672"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03691-1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.5339\/gcsp.2013.38"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1586\/erd.11.27"},{"key":"e_1_2_6_18_3","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4368910"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.71"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2271"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1515\/revce-2015-0074"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201502003"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2891"},{"key":"e_1_2_6_21_3","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4474"},{"key":"e_1_2_6_21_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06457-9"},{"key":"e_1_2_6_21_5","doi-asserted-by":"publisher","DOI":"10.1021\/la100623y"},{"key":"e_1_2_6_21_6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09587-y"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-010-0208-z"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.03.046"},{"key":"e_1_2_6_22_3","first-page":"1093","volume":"8","author":"Bian Z.","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"e_1_2_6_22_4","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-009-0424-6"},{"key":"e_1_2_6_22_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.09.033"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-32889-0.00002-9"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S36111"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.20911"},{"key":"e_1_2_6_25_1","first-page":"61","volume-title":"Synthesis and Primary Characterization of Self\u2010Assembled Peptide\u2010Based Hydrogels","author":"Nagarkar R. P.","year":"2008"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC04477D"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201911782"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja408182p"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.142309999"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(93)90361-H"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.06.002"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2017.0028"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201205234"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0sm00642d"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2016.11.008"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2018.00099"},{"key":"e_1_2_6_35_1","volume-title":"ASTM F756\u201017: Standard Practice for Assement of Hemolytic Properites of Materials","year":"2017"},{"key":"e_1_2_6_36_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-1-62703-339-8_12","volume-title":"Haemostasis \u2013 Methods and Protocols","author":"Horton S.","year":"2013"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00504"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.160696"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00249-015-1019-8"},{"key":"e_1_2_6_38_3","doi-asserted-by":"publisher","DOI":"10.1007\/s12154-009-0027-5"},{"key":"e_1_2_6_38_4","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S159785"}],"container-title":["Advanced Functional Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adfm.202007733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adfm.202007733","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/adfm.202007733","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adfm.202007733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T19:23:28Z","timestamp":1759778608000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adfm.202007733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,14]]},"references-count":75,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/adfm.202007733"],"URL":"https:\/\/doi.org\/10.1002\/adfm.202007733","archive":["Portico"],"relation":{},"ISSN":["1616-301X","1616-3028"],"issn-type":[{"value":"1616-301X","type":"print"},{"value":"1616-3028","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,14]]},"assertion":[{"value":"2020-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2007733"}}