{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:31:02Z","timestamp":1792693862975,"version":"4.5.0"},"reference-count":142,"publisher":"Wiley","issue":"44","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DC015050"],"award-info":[{"award-number":["DC015050"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DC015557"],"award-info":[{"award-number":["DC015557"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Funct Materials"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The prevalence of ear disorders has spurred efforts to develop drug delivery systems to treat these conditions. Here, recent advances in drug delivery systems that access the ear through the tympanic membrane (TM) are reviewed. Such methods are either non\u2010invasive (placed on the surface of the TM), or invasive (placed in the middle ear, ideally on the round window [RW]). The major hurdles to otic drug delivery are identified and highlighted the representative examples of drug delivery systems used for drug delivery across the TM to the middle and (crossing the RW also) inner ear.<\/jats:p>","DOI":"10.1002\/adfm.202008701","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T05:22:37Z","timestamp":1607059357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Drug Delivery across Barriers to the Middle and Inner Ear"],"prefix":"10.1002","volume":"31","author":[{"given":"Zipei","family":"Zhang","sequence":"first","affiliation":[{"name":"Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Boston Children's Hospital Harvard Medical School  Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyu","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Boston Children's Hospital Harvard Medical School  Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Boston Children's Hospital Harvard Medical School  Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5369-5932","authenticated-orcid":false,"given":"Daniel S.","family":"Kohane","sequence":"additional","affiliation":[{"name":"Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Boston Children's Hospital Harvard Medical School  Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201606596"},{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep22663"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912254"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(05)70309-6"},{"key":"e_1_2_7_2_3","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.210"},{"key":"e_1_2_7_2_4","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113719"},{"key":"e_1_2_7_2_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.06.047"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.09.030"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/5507"},{"key":"e_1_2_7_3_3","doi-asserted-by":"publisher","DOI":"10.3201\/eid1106.050198"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000261"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2007.09.017"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488809125107"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aao0935"},{"key":"e_1_2_7_5_3","first-page":"72","volume":"7","author":"Juhn S. K.","year":"2001","journal-title":"Int. Tinnitus J."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00493"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2010.12.023"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12344"},{"key":"e_1_2_7_7_2","volume-title":"The Auditory System: Anatomy, Physiology, and Clinical Correlates","author":"Musiek F. E.","year":"2018"},{"key":"e_1_2_7_7_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2013.02.001"},{"key":"e_1_2_7_7_4","doi-asserted-by":"publisher","DOI":"10.1016\/S1672-2930(09)50002-5"},{"key":"e_1_2_7_7_5","volume-title":"Hearing and Sound Communication in Fishes","author":"Tavolga W. N.","year":"2012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2013.04.014"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-013-0394-z"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27239"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2018.1464022"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000187044.73791.92"},{"key":"e_1_2_7_10_3","doi-asserted-by":"publisher","DOI":"10.1080\/00016489850154748"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2018.05.020"},{"key":"e_1_2_7_11_2","first-page":"51","volume-title":"Chronic Otitis Media. Pathogenesis\u2010Oriented Therapeutic Management","author":"Decraemer W. F.","year":"2008"},{"key":"e_1_2_7_11_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijengsci.2010.02.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.01.004"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(00)00177-5"},{"key":"e_1_2_7_12_3","doi-asserted-by":"publisher","DOI":"10.1023\/B:ABME.0000030260.22737.53"},{"key":"e_1_2_7_12_4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232862"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2013.10.020"},{"key":"e_1_2_7_13_2","volume-title":"Occupational Exposure to Noise: Evaluation, Prevention and Control","author":"Goelzer B.","year":"2001"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2006.08.011"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941212100209"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318254590e"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2017.12.010"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-071813-105206"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.08.015"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-011-0159-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488809107371"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2013.766167"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082575"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181eb32d1"},{"key":"e_1_2_7_20_1","first-page":"277","volume":"105","author":"Salt A. N.","year":"2005","journal-title":"Volta Rev."},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2009.11.003"},{"key":"e_1_2_7_20_3","doi-asserted-by":"publisher","DOI":"10.1159\/000313506"},{"key":"e_1_2_7_20_4","doi-asserted-by":"publisher","DOI":"10.1159\/000241896"},{"key":"e_1_2_7_20_5","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.12.5"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1672-2930(09)50006-2"},{"key":"e_1_2_7_22_1","volume-title":"Schuknecht's Pathology of the Ear","author":"Merchant S. N.","year":"2010"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31818a08e8"},{"key":"e_1_2_7_22_3","volume-title":"The Cochlea","author":"Dallos P.","year":"2012"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2011.01.010"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.06.004"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32830e20db"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31815aee21"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(01)00167-1"},{"key":"e_1_2_7_26_1","first-page":"43","volume":"493","author":"Goycoolea M. V.","year":"1992","journal-title":"Acta Oto\u2010Laryngol., Suppl."},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21370"},{"key":"e_1_2_7_26_3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19970201)36:3<201::AID-JEMT8>3.0.CO;2-R"},{"key":"e_1_2_7_26_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.joto.2016.11.002"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.02.040"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde.12.130"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31818658ea"},{"key":"e_1_2_7_28_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.10.025"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200303000-00034"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2004.04.003"},{"key":"e_1_2_7_29_3","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf4363"},{"key":"e_1_2_7_30_1","first-page":"521","volume":"122","author":"Chandrasekhar S. S.","year":"2000","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"e_1_2_7_31_1","volume-title":"Int. Symp. on Recent Advances in Otitis Media","author":"Sabharwal Y. R. V.","year":"2019"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-006-9104-4"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.04.028"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-7799(00)01485-2"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501176102"},{"key":"e_1_2_7_35_1","first-page":"4688","volume":"102","author":"Sloan K. B.","year":"2005","journal-title":"Drug Delivery"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(01)00271-1"},{"key":"e_1_2_7_35_3","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(95)04108-7"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b01235"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.06.019"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S596"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2017.03.003"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.03.005"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2010.06.034"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.2147\/RRTD.S64773"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.01.037"},{"key":"e_1_2_7_43_1","volume-title":"Int. Symp. on Recent Advances in Otitis Media","author":"Sharma P. A. K. G.","year":"2019"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172158"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30031-6"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2017.1252751"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.02.016"},{"key":"e_1_2_7_48_1","first-page":"307","volume":"42","author":"Edmunds A. L.","year":"2017","journal-title":"Pharm. Ther."},{"key":"e_1_2_7_48_2","unstructured":"b) Otonomy https:\/\/www.otonomy.com\/press\/otonomy\u2010initiates\u2010phase\u20101\u2010clinical\u2010trial\u2010for\u2010tinnitus\u2010product\u2010candidate\u2010oto\u2010311\/ accessed: May2020;"},{"key":"e_1_2_7_48_3","unstructured":"c) Otonomy https:\/\/www.otonomy.com\/pipeline\/ accessed: April2020;"},{"key":"e_1_2_7_48_4","unstructured":"d) Fennecpharma https:\/\/fennecpharma.com\/product\u2010candidates\/pedmark\/clinical\u2010trials\/ accessed: May2020;"},{"key":"e_1_2_7_48_5","unstructured":"e) Aurismedical https:\/\/aurismedical.com\/product\u2010candidates\/am\u2010111 accessed: May2020."},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002229"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/03655230601065332"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2005.09.023"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0b013e3181c351f2"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2020.03.005"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.11.066"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201003963"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.04.019"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.02.037"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2006.06.001"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.05.230"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v7i3.14694"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.12.031"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31815f8e41"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348941212100311"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0219-x"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2013.789054"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.2174\/1567201811666140118224616"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.02.048"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2018.03.006"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480600895102"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.04.038"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2010.02.003"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.09.025"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.115972"},{"key":"e_1_2_7_69_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn4058787"},{"key":"e_1_2_7_69_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.12.027"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.11.032"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2019.1573182"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.04.028"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2017.1373803"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.02.013"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00268"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2018.06.011"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.132880"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.01.032"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.08.016"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.123415"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2017.20"},{"key":"e_1_2_7_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08690-4"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1039\/C0SC00203H"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.02.016"}],"container-title":["Advanced Functional Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adfm.202008701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adfm.202008701","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adfm.202008701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T10:26:38Z","timestamp":1759746398000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adfm.202008701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,4]]},"references-count":142,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/adfm.202008701"],"URL":"https:\/\/doi.org\/10.1002\/adfm.202008701","archive":["Portico"],"relation":{},"ISSN":["1616-301X","1616-3028"],"issn-type":[{"value":"1616-301X","type":"print"},{"value":"1616-3028","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,4]]},"assertion":[{"value":"2020-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2008701"}}