{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:39:44Z","timestamp":1791178784205,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T00:00:00Z","timestamp":1639785600000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1410853"],"award-info":[{"award-number":["1410853"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1809229"],"award-info":[{"award-number":["1809229"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP2DK111910"],"award-info":[{"award-number":["DP2DK111910"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK123293"],"award-info":[{"award-number":["R01DK123293"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Funct Materials"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Postoperative peritoneal adhesions are frequent complications for almost any type of abdominal and pelvic surgery. This leads to numerous medical problems and a huge financial burden to the patients. Current anti\u2010adhesion strategies focus mostly on physical barriers including films and hydrogels. However, they can only alleviate or reduce adhesions to a certain level and their applying processes are far from ideal. This work reported the development of a biodegradable zwitterionic cream gel presenting a series of characters for an ideal anti\u2010adhesion material, including unique injectable yet malleable and self\u2010supporting properties, which enables an instant topical application, no curing, waiting, or suturing, no hemostasis requirement, protein\/cell resistance, and biodegradability. The cream gel shows a major advancement in anti\u2010adhesion efficacy by completely and reliably preventing a primary and more severe recurrent adhesion in rat models.<\/jats:p>","DOI":"10.1002\/adfm.202009431","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T11:24:03Z","timestamp":1608290643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Biodegradable Zwitterionic Cream Gel for Effective Prevention of Postoperative Adhesion"],"prefix":"10.1002","volume":"31","author":[{"given":"Ershuai","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Wayne State University  Detroit MI 48202 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Wayne State University  Detroit MI 48202 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Wayne State University  Detroit MI 48202 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Wayne State University  Detroit MI 48202 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Wayne State University  Detroit MI 48202 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangfei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Wayne State University  Detroit MI 48202 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjie","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Wayne State University  Detroit MI 48202 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengbiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Wayne State University  Detroit MI 48202 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Wayne State University  Detroit MI 48202 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0114-2249","authenticated-orcid":false,"given":"Zhiqiang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Wayne State University  Detroit MI 48202 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"e_1_2_8_1_1","first-page":"60","volume":"72","author":"Menzies D.","year":"1990","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-013-0591-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-011-1819-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.6.567"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000050149"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61687-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-002-9208-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.12.084"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12979-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.06.034"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004230000190"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.05.037"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004640000256"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2016.09.021"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13353"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31826f4969"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f5588"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.01.050"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.7b00605"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0442-z"},{"key":"e_1_2_8_21_1","unstructured":"Ethicon US LLC GYNECARE INTERCEED Absorbable Adhesion Barrier Instructions for Use https:\/\/www.jnjmedicaldevices.com\/en\u2010US\/product\/gynecare\u2010interceed\u2010absorbable\u2010adhesion\u2010barrier 2019."},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.8.1764"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(98)00057-0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/gyn.1991.7.97"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3PY01358H"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.0c00889"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b01333"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.04.043"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.08.047"},{"key":"e_1_2_8_30_1","first-page":"59","volume":"83","author":"Hill\u2010West J. L.","year":"1994","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.03.110"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.04.003"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110661"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200901407"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja054169u"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3488-9"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.12.002"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2013.04.023"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr300358b"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm5011883"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1082389"},{"key":"e_1_2_8_42_1","first-page":"547","volume":"7","author":"Yang B.","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep13553"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b13184"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2007.04.016"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201606506"}],"container-title":["Advanced Functional Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adfm.202009431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adfm.202009431","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/adfm.202009431","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adfm.202009431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T11:22:37Z","timestamp":1759749757000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adfm.202009431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,18]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/adfm.202009431"],"URL":"https:\/\/doi.org\/10.1002\/adfm.202009431","archive":["Portico"],"relation":{},"ISSN":["1616-301X","1616-3028"],"issn-type":[{"value":"1616-301X","type":"print"},{"value":"1616-3028","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,18]]},"assertion":[{"value":"2020-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2009431"}}