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However, fibrotic tissue deposition around the device has been shown to compromise the long\u2010term function of the transplanted cells. Herein, a macroencapsulation device design that improves long\u2010term survival and function of the transplanted cells is reported. The device is comprised of a semipermeable chitosan pouch with a tunable reservoir and molecularly engineered interface. The chitosan pouch interface decorated with 1,12\u2010dodecanedioic acid (DDA), limits the cell adhesion and vigorous foreign body response while maintaining the barrier properties amenable to cell encapsulation. The device provides long\u2010term protection to the encapsulated human primary hepatocytes in the subcutaneous space of immunocompetent mice. The device supports the encapsulated cells for up to 6 months as evident from cell viability and presence of human specific albumin in circulation. Solutions that integrate biomaterials and interfacial engineering such as the one described here may advance development of easy\u2010to manufacture and retrievable devices for the transplantation of therapeutic cells in the absence of immunosuppression.<\/jats:p>","DOI":"10.1002\/adfm.202108221","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T03:22:34Z","timestamp":1633749754000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Molecularly Tailored Interface for Long\u2010Term Xenogeneic Cell Transplantation"],"prefix":"10.1002","volume":"32","author":[{"given":"Sajeesh Kumar","family":"Madhurakkat Perikamana","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Duke University School of Medicine  Durham NC 27710 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