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Here, the validated methodology is reported for a novel hybrid tissue\u2010engineered vascular graft that aims to match the natural structure of small\u2010size arteries. The blood vessel mimic (BVM) comprises an internal conduit of co\u2010electrospun gelatin\u00a0and polycaprolactone (PCL) nanofibers (corresponding to the tunica intima of an artery), reinforced by an additional layer of PCL aligned fibers (the internal elastic membrane). Endothelial cells are deposited onto the luminal surface using a rotative bioreactor. A bioprinting system extrudes two concentric cell\u2010laden hydrogel layers containing respectively vascular smooth muscle cells\u00a0and pericytes to create the tunica media and adventitia. The semi\u2010automated cellularization process reduces the production and maturation time to 6 days. After the evaluation of mechanical properties, cellular viability, hemocompatibility, and suturability, the BVM is successfully implanted in the left pulmonary artery\u00a0of swine. Here, the BVM showed good hemostatic properties, capability to withstand blood pressure, and patency at 5 weeks post\u2010implantation. 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