{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:54:14Z","timestamp":1788519254476,"version":"build-2803163510"},"reference-count":151,"publisher":"Wiley","issue":"37","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR002490"],"award-info":[{"award-number":["KL2TR002490"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Funct Materials"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alzheimer's disease (AD) is one of the main causes of dementia worldwide, whereby neuronal death or malfunction leads to cognitive impairment in the elderly population. AD is highly prevalent, with increased projections over the next few decades. Yet current diagnostic methods for AD occur only after the presentation of clinical symptoms. Evidence in the literature points to potential mechanisms of AD induction beginning before clinical symptoms start to present, such as the formation of amyloid beta (A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    ) extracellular plaques and neurofibrillary tangles (NFTs). Biomarkers of AD, including A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:sub>40<\/jats:sub>\n                    , A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:sub>42<\/jats:sub>\n                    , and tau protein, amongst others, show promise for early AD diagnosis. Additional progress is made in the application of biosensing modalities to measure and detect significant changes in these AD biomarkers within patient samples, such as cerebral spinal fluid (CSF) and blood, serum, or plasma. Herein, a comprehensive review of the emerging nano\u2010biomaterial approaches to develop biosensors for AD biomarkers\u2019 detection is provided. Advances, challenges, and potential of electrochemical, optical, and colorimetric biosensors, focusing on nanoparticle\u2010based (metallic, magnetic, quantum dots) and nanostructure\u2010based biomaterials are discussed. Finally, the criteria for incorporating these emerging nano\u2010biomaterials in clinical settings are presented and assessed, as they hold great potential for enhancing early\u2010onset AD diagnostics.\n                  <\/jats:p>","DOI":"10.1002\/adfm.202302673","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T10:06:02Z","timestamp":1684922762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Functional Nanomaterials for the Diagnosis of Alzheimer's Disease: Recent Progress and Future Perspectives"],"prefix":"10.1002","volume":"33","author":[{"given":"Saqer Al","family":"Abdullah","sequence":"first","affiliation":[{"name":"Department of Nanoengineering Joint School of Nanoscience and Nanoengineering North Carolina A&amp;T State University  2907 East Gate City Boulevard Greensboro NC 27401 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1280 Main Street West Hamilton ON L8S 4L7 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Al\u2010Jabouri","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biomedical Sciences McMaster University  1280 Main Street West Hamilton ON L8S 4K1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8757-8002","authenticated-orcid":false,"given":"Tohid F.","family":"Didar","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering McMaster University  1280 Main Street West Hamilton ON L8S 4L8 Canada"},{"name":"Department of Mechanical Engineering McMaster University  1280 Main Street West Hamilton ON L8S 4L7 Canada"},{"name":"Institute for Infectious Disease Research (IIDR)  1280 Main St W, McMaster University Hamilton ON L8S 4L8 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