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In this study, a stretchable antifouling coating named lubricant\u2010infused poly(1,3,5,7\u2010tetramethyl\u20101,3,5,7\u2010tetravinyl cyclotetrasiloxane) (V4D4) is introduced interface with perfluoropolymer (L\u2010VIP). The stretchable adhesive\u2010perfluoropolymer bilayer comprises stretchable adhesive polymer (V4D4) and perfluoropolymer (1H,1H,2H,2H\u2010perfluorooctyl methacrylate (FOMA)). The bilayer exhibits a strong affinity with the lubricant, imparting exceptional antifouling and slippery properties. L\u2010VIP coating displays superior fouling resistance against plasma proteins related to foreign body reactions (FBR) and biofilm\u2010forming bacteria. The coating exhibits impressive elastic limits exceeding 200% strain and exceptional stability under repeated cyclic stretching (&gt; 2000 cycles at 150% strain) while maintaining its antifouling properties. Furthermore, the coating presents dielectric performance under accelerated aging conditions at a temperature of 70\u00b0 and constant voltage stress of 10\u00a0V\u00a0s<jats:sup>\u22121<\/jats:sup> for over 50 days. To assess the biocompatibility of the L\u2010VIP coating, a series of in vitro and in vivo experiments are conducted, confirming its non\u2010toxicity for biomedical applications. It is expected that the stretchable L\u2010VIP coating will enhance medical devices\u2019 longevity and help prevent bacterial infections, the formation of biofilms, and the nonspecific adherence of biological substances after implantation.<\/jats:p>","DOI":"10.1002\/adfm.202312740","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T22:56:11Z","timestamp":1703631371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Lubricant\u2010Infused Polymeric Interfaces: A Stretchable and Anti\u2010Fouling Surface for Implantable Biomaterials"],"prefix":"10.1002","volume":"34","author":[{"given":"Tae Young","family":"Kim","sequence":"first","affiliation":[{"name":"School of Electrical and Electronic Engineering Yonsei University  50\u20131 Yonsei\u2010ro, Seodaemun\u2010gu Seoul 03722 Republic of 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