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Herein, the co\u2010hydrolysis and co\u2010condensation of a mixture of organosilanes followed by the epoxy\u2010amine ring opening reaction at the interface results in a highly robust, transparent, and <jats:italic>\u201cliquid\u2010like\u201d<\/jats:italic> solid slippery omniphobic coating (LL\u2010OSC). The presence of the epoxy\u2010terminated organosilane a) acts as a molecular spacer in between the low\u2010surface energy, rigid fluorine terminated silane and b) provides \u201creactive\u201d epoxy groups for covalent binding to a pre\u2010functionalized amine surface for potential applicability in droplet transport and manipulation, diagnostics, etc. LL\u2010OSC exhibits resistance to both solid and liquid abrasions such as sandpaper abrasions, prolonged UV irradiation, DI water and high temperature (30 days), and submersion in chemically contaminated aqueous solutions. This is the first report of a hemocompatible solid slippery coating for inhibiting platelet adhesion, thus, paving way for blood\u2010contacting medical device applications. The LL\u2010OSC exhibits remarkable cytocompatibility, repellence to plasma protein, and cells and prevents biofilm formation. Additionally, the substrate\u2010independent LL\u2010OSC can be applied onto metals and polymers. This study envisions that the reported durable, solid slippery coating will find widespread applicability in hospital settings, electronic devices, etc.<\/jats:p>","DOI":"10.1002\/adfm.202401387","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T09:11:25Z","timestamp":1713431485000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["\u201cReactive\u201d Chemical Strategy to Attain Substrate Independent \u201c<i>Liquid\u2010Like<\/i>\u201d Omniphobic Solid Anti\u2010Biofouling Coatings"],"prefix":"10.1002","volume":"34","author":[{"given":"Arpita","family":"Shome","sequence":"first","affiliation":[{"name":"School of Chemical Materials and Biomedical Engineering University of Georgia  Athens GA 30602 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Martinez","sequence":"additional","affiliation":[{"name":"School of Chemical Materials and 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