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However, intratumoral (i.t.) injection of naked NPs may result in poor dispersion and backflow resulting in leakage and rapid clearance, limiting therapeutic outcome and increasing off\u2010target toxicity. To overcome these limitations, we employed tumor\u2010tropic human mesenchymal stem cells (hMSCs) as delivery vehicles for magnetotheranostic gold\u2013iron oxide nanoflowers (GIONF), enabling widespread i.t. distribution and sustained retention in contrast to injection of naked GIONF. GIONF\u2010hMSCs demonstrated superior heating performance under near\u2010infrared laser irradiation while exhibiting a strong magnetic particle imaging (MPI) signal, allowing for noninvasive quantitative tracking of their whole body biodistribution. Laser irradiation at peak GIONF\u2010hMSC retention resulted in complete tumor ablation without recurrence up to 90 days post\u2010treatment. 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