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Herein, we report a class of biocompatible nanogels with controllable onset of glucose response for self\u2010regulated insulin delivery. The narrowly distributed nanogels are prepared via controlled polymerization using the poly[oligo(ethylene glycol) methyl ether methacrylate (M\n                    <jats:sub>n<\/jats:sub>\n                    = 500)] (pMEO\n                    <jats:sub>9<\/jats:sub>\n                    MA) as macro\u2010chain transfer agents copolymerized with 4\u2010vinylphenylboronic acid (VPBA) and a crosslinker. The nanogels can be freeze\u2010dried and easily redispersed in an aqueous phase with excellent colloidal stability. The pMEO\n                    <jats:sub>9<\/jats:sub>\n                    MA chain length and pMEO\n                    <jats:sub>9<\/jats:sub>\n                    MA\/VPBA ratio enable tuning both particle size and the onset of glucose responsiveness of the nanogels. A single injection of the insulin\u2010loaded nanogels can maintain normoglycemia in diabetic mice for up to 18\u00a0h. Importantly, the dose increase in the nanogel\u2010insulin prolongs the duration of normoglycemia but does not cause hypoglycemia in diabetic mice, benefiting from the reversible on\u2010off insulin delivery at the desirable glucose threshold. The nanogels exhibit no cytotoxicity or organ toxicity after repeated dosing in vivo. These results highlight great promise for developing swelling\u2010based nanogels for long\u2010acting GRID systems.\n                  <\/jats:p>","DOI":"10.1002\/adfm.78536","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:24:10Z","timestamp":1789701850000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biocompatible Nanogels Synthesized via RAFT Polymerization for Long\u2010Acting Onset\u2010Controllable Glucose\u2010Responsive Insulin Delivery in Diabetic Mice"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3973-2669","authenticated-orcid":false,"given":"Koushik","family":"Bhattacharya","sequence":"first","affiliation":[{"name":"Department of Chemistry The College of Staten Island, and The Ph. D. Program in Chemistry of Graduate Center The City University of New York  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangtao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry The College of Staten Island, and The Ph. D. Program in Chemistry of Graduate Center The City University of New York  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashun G.","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Chemistry The College of Staten Island, and The Ph. D. Program in Chemistry of Graduate Center The City University of New York  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrunmaya Kumar","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Chemistry The College of Staten Island, and The Ph. D. Program in Chemistry of Graduate Center The City University of New York  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhasmita","family":"Mohapatra","sequence":"additional","affiliation":[{"name":"Department of Chemistry The College of Staten Island, and The Ph. D. Program in Chemistry of Graduate Center The City University of New York  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9429-1010","authenticated-orcid":false,"given":"Probal","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Chemistry The College of Staten Island, and The Ph. D. Program in Chemistry of Graduate Center The City University of New York  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2257-6150","authenticated-orcid":false,"given":"Shuiqin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Chemistry The College of Staten Island, and The Ph. D. 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaf177"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1916\/j.addr.2022.114280"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010023\u201001565\u20102"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202300127"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dbi23\u20100028"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialsau.4c00138"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbac056"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16101343"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201300120"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.01.043"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym17060780"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010021\u201005422\u20106"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn401617u"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b04484"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120458"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.08.017"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.2c00016"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2013.12.067"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3py00778b"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.03.030"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels10040260"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.11.261"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9nr01554j"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202402556"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c00067"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.1c00772"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3py01202f"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.05.029"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5pm00083a"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24061089"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2023.112061"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2025.114086"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaq0723"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41428\u2010021\u201000525\u20108"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308965"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.06.016"},{"issue":"10","key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/s41551-023-01138-7","article-title":"Week\u2010Long 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