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Here, we assess the impact of collagen scaffolds on mouse full\u2010thickness wound re\u2010epithelialisation during the first 5 days of healing. We find that scaffolds impede wound re\u2010epithelialisation, inducing a bulbous thickening of the wound edge epidermis as opposed to the thin tongue of migratory keratinocytes seen in normal wound healing. Scaffolds also increase the inflammatory response and the numbers of neutrophils in and around the wound. These effects were also produced by scaffolds made of alginate in the form of fibers and microspheres, but not as an alginate hydrogel. In addition, we find the gap junction protein connexin 43, which normally down\u2010regulates at the wound edge during re\u2010epithelialisation, to be up\u2010regulated in the bulbous epidermal wound edge. Incorporation of connexin 43 antisense oligodeoxynucleotides into the scaffold can be performed to reduce inflammation whilst promoting scaffold biocompatibility.<\/jats:p>","DOI":"10.1002\/adhm.201200357","type":"journal-article","created":{"date-parts":[[2013,2,18]],"date-time":"2013-02-18T19:48:09Z","timestamp":1361216889000},"page":"1151-1160","source":"Crossref","is-referenced-by-count":26,"title":["Integration of Scaffolds into Full\u2010Thickness Skin Wounds: The Connexin Response"],"prefix":"10.1002","volume":"2","author":[{"given":"Daniel J.","family":"Gilmartin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maia M.","family":"Alexaline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Thrasivoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony R. 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