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Although the possibility of stabilizing amorphous drugs inside nano\u2010sized pores of carbon nanotubes and ordered mesoporous silica has been shown, no conventional pharmaceutical excipients have so far been shown to possess this property. This study demonstrates the potential of using CaCO<jats:sub>3<\/jats:sub>, a widely used excipient in oral drug formulations, to stabilize the amorphous state of active pharmaceutical ingredients, in particular celecoxib. After incorporation of celecoxib in the vaterite particles, a five to sixfold enhancement in apparent solubility of celecoxib is achieved due to pore\u2010induced amorphization. To eliminate the possibility of uncontrolled phase transitions, the vaterite particles are stored in an inert atmosphere at 5 \u00b0C throughout the study. Also, to demonstrate that the amorphization effect is indeed associated with vaterite mesopores, accelerated stress conditions of 100% relative humidity are employed to impose transition from mesoporous vaterite to an essentially non\u2010porous aragonite phase of CaCO<jats:sub>3<\/jats:sub>, which shows only limited amorphization ability. Further, an improvement in solubility is also confirmed for ketoconazole when formulated with the mesoporous vaterite. Synthesis of the carrier particles and the incorporation of the active substances are carried out simultaneously in a one\u2010step procedure, enabling easy fabrication. These results represent a promising approach to achieve enhanced bioavailability in new formulations of Type II BCS drugs.<\/jats:p>","DOI":"10.1002\/adhm.201200391","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T10:37:36Z","timestamp":1369305456000},"page":"1469-1476","source":"Crossref","is-referenced-by-count":31,"title":["Mesoporous Calcium Carbonate as a Phase Stabilizer of Amorphous Celecoxib \u2013 An Approach to Increase the Bioavailability of Poorly Soluble Pharmaceutical 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