{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:23:27Z","timestamp":1791271407119,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Liver X receptors (LXRs) attenuate inflammation by modulating the expression of key inflammatory genes, making LXRs and their ligands particularly attractive candidates for therapeutic intervention in cardiovascular, metabolic, and\/or inflammatory diseases. Herein, enhanced proresolving activity of polymeric nanoparticles (NPs) containing the synthetic LXR agonist GW3965 (LXR\u2010NPs) is demonstrated, developed from a combinatorial library of more than 70 formulations with variations in critical physicochemical parameters. In vitro studies on peritoneal macrophages confirm that LXR\u2010NPs are significantly more effective than the free agonist at downregulating pro\u2010inflammatory mediators (MCP\u20101 and TNF\u03b1), as well as inducing the expression of LXR target genes (ABCA1 and SREBP1c). Through a zymosan\u2010induced acute peritonitis in vivo model, LXR\u2010NPs are found to be more efficient than free GW3965 at limiting the recruitment of polymononuclear neutrophils (50% vs 17%), suppressing the gene expression and secretion of pro\u2010inflammatory factors MCP\u20101 and TNF\u03b1 in peritoneal macrophages, and decreasing the resolution interval up to 4 h. Furthermore, LXR\u2010NPs suppress the secretion of MCP\u20101 and TNF\u03b1 by monocytes and macrophages more efficiently than the commercial drug dexamethasone. Overall, these findings demonstrate that LXR\u2010NPs are capable of promoting resolution of inflammation and highlight the prospect of LXR\u2010based nanotherapeutics for inflammatory diseases.<\/jats:p>","DOI":"10.1002\/adhm.201300688","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T05:53:55Z","timestamp":1395640435000},"page":"1448-1456","source":"Crossref","is-referenced-by-count":35,"title":["Development of Therapeutic Polymeric Nanoparticles for the Resolution of Inflammation"],"prefix":"10.1002","volume":"3","author":[{"given":"Suresh","family":"Gadde","sequence":"first","affiliation":[{"name":"Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School  Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orli","family":"Even\u2010Or","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and the Leon H. 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