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PEDs contain a core of high\u2010density perfluorodecalin measuring \u226435 \u03bcm in diameter surrounded and stabilized by fluorescein\u2010tagged, polystyrene nanoparticles that simulate polymeric drug carriers. A hollow microneedle infuses PEDs into the suprachoroidal space of rabbit eyes in vivo, which are later dissected and imaged to quantify distribution of fluorescent nanoparticles within the suprachoroidal space. With cornea oriented upward, such that gravity should move PEDs toward the back of the eye, up to 50% of nanoparticles are in the most posterior quadrant near the macula immediately after injection and 5 d later. With cornea oriented downward, to promote PED movement toward the front of the eye, approximately 60% of injected nanoparticles are targeted to the most anterior quadrant of the posterior segment near ciliary body. Injection of approximately neutral\u2010density particles of the same size shows approximately equal distribution throughout the posterior segment. This study demonstrates for the first time that high\u2010density PEDs can be used to deliver nanoparticles to specific locations in the back of the eye, including targeted delivery to the macula.<\/jats:p>","DOI":"10.1002\/adhm.201300696","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T14:47:13Z","timestamp":1395326833000},"page":"1272-1282","source":"Crossref","is-referenced-by-count":36,"title":["Particle\u2010Stabilized Emulsion Droplets for Gravity\u2010Mediated Targeting in the Posterior Segment of the Eye"],"prefix":"10.1002","volume":"3","author":[{"given":"Yoo C.","family":"Kim","sequence":"first","affiliation":[{"name":"School of Chemical and Biomolecular Engineering Georgia Institute of Technology  311 Ferst Drive NW Atlanta GA 30332 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry F.","family":"Edelhauser","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Emory University School of Medicine  1365 Clifton Rd NE Atlanta GA 30322 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Prausnitz","sequence":"additional","affiliation":[{"name":"School of Chemical and Biomolecular Engineering Georgia Institute of Technology  311 Ferst Drive NW Atlanta GA 30332 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,20]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.4.564"},{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.12.1740"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200868080-00002"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181a94f01"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.06.045"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.4.4.371"},{"key":"e_1_2_7_4_1","first-page":"353","volume-title":"Pharmacological Reports: PR 2006","author":"Nowak J. 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