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However, current technologies cannot differentiate more lethal \u201cvulnerable plaques,\u201d and are not sensitive enough for preventive medicine. Imaging early molecular markers and quantifying the extent of disease progression continues to be a major challenge in the field. To this end, monocyte\u2010targeting, peptide amphiphile micelles (PAMs) are engineered through the incorporation of the chemokine receptor CCR2\u2010binding motif of monocyte chemoattractant protein\u20101 (MCP\u20101) and MCP\u20101 PAMs are evaluated preclinically as diagnostic tools for atherosclerosis. Monocyte\u2010targeting is desirable as the influx of monocytes is a marker of early lesions, accumulation of monocytes is linked to atherosclerosis progression, and rupture\u2010prone plaques have higher numbers of monocytes. MCP\u20101 PAMs bind to monocytes in vitro, and MCP\u20101 PAMs detect and discriminate between early\u2010 and late\u2010stage atherosclerotic aortas. Moreover, MCP\u20101 PAMs are found to be eliminated via renal clearance and the mononuclear phagocyte system (MPS) without adverse side effects. Thus, MCP\u20101 PAMs are a promising new class of diagnostic agents capable of monitoring the progression of atherosclerosis.<\/jats:p>","DOI":"10.1002\/adhm.201400336","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T11:38:45Z","timestamp":1408707525000},"page":"367-376","source":"Crossref","is-referenced-by-count":51,"title":["Monocyte\u2010Targeting Supramolecular Micellar Assemblies: A Molecular Diagnostic Tool for Atherosclerosis"],"prefix":"10.1002","volume":"4","author":[{"given":"Eun Ji","family":"Chung","sequence":"first","affiliation":[{"name":"Institute for Molecular Engineering University of Chicago  5747 S. 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