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Although Ga<jats:sup>3+<\/jats:sup> can inhibit or kill biofilms, precipitation as Ga(OH)<jats:sub>3<\/jats:sub> has prevented its use as a topical wound treatment. The design of a microfilm construct comprising a polyelectrolyte film that releases noncytotoxic concentrations of Ga<jats:sup>3+<\/jats:sup> over 20 d and a dissolvable micrometer\u2010thick film of polyvinylalcohol that enables facile transfer onto biomedically important surfaces is reported. By using infrared spectroscopy, it is shown that the density of free carboxylate\/carboxylic acid and amine groups within the polyelectrolyte film regulates the capacity of the construct to be loaded with Ga<jats:sup>3+<\/jats:sup> and that the density of covalent cross\u2010links introduced into the polyelectrolyte film (amide\u2010bonds) controls the release rate of Ga<jats:sup>3+<\/jats:sup>. Following transfer onto the wound\u2010contact surface of a biologic wound dressing, an optimized construct is demonstrated to release \u22480.7 \u03bcg cm<jats:sup>\u22122<\/jats:sup> d<jats:sup>\u22121<\/jats:sup> of Ga<jats:sup>3+<\/jats:sup> over 3 weeks, thus continuously replacing Ga<jats:sup>3+<\/jats:sup> lost to precipitation. The optimized construct inhibits formation of <jats:italic>P. aeruginosa<\/jats:italic> (two strains; ATCC 27853 and PA01) biofilms for up to 4 d and causes pre\u2010existing biofilms to disperse. Overall, this study provides designs of polymeric constructs that permit facile modification of the wound\u2010contacting surfaces of dressings and biomaterials to manage biofilms.<\/jats:p>","DOI":"10.1002\/adhm.201500599","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T08:50:00Z","timestamp":1448355000000},"page":"2849-2859","source":"Crossref","is-referenced-by-count":12,"title":["Gallium\u2010Loaded Dissolvable Microfilm Constructs that Provide Sustained Release of Ga<sup>3+<\/sup> for Management of Biofilms"],"prefix":"10.1002","volume":"4","author":[{"given":"Maggie","family":"Herron","sequence":"first","affiliation":[{"name":"Department of Chemical and Biological Engineering University of Wisconsin  1415 Engineering Drive Madison WI 53706 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Schurr","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medicine University of Colorado\u2010Denver  12631 E. 17th Avenue Aurora CO 80045 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences School of Medicine Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California\u2010Davis  1423 Tupper Hall Davis CA 95616 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan F.","family":"McAnulty","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences School of Veterinary Medicine University of Wisconsin\u2010Madison  2015, Linden Dr Madison WI 53706 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Czuprynski","sequence":"additional","affiliation":[{"name":"Department of Pathobiology School of Veterinary Medicine University of Wisconsin\u2010Madison  2015, Linden Dr Madison WI 53706 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