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In order to ameliorate their regenerative effects, various biomaterials are being investigated for their potential supportive properties. Here, gelatin microspheres (MS) are utilized as microcarriers to improve the delivery and therapeutic efficacy of cardiac progenitor cells (CPCs) in the ischemic myocardium. The gelatin MS, generated from a water\u2010in\u2010oil emulsion, are able to accommodate the attachment of CPCs, thereby maintaining their cardiogenic potential. In a mouse model of myocardial infarction, we demonstrated the ability of these microcarriers to substantially enhance cell engraftment in the myocardium as indicated by bioluminescent imaging and histological analysis. However, despite an observed tenfold increase in CPC numbers in the myocardium, echocardiography, and histology reveals that mice treated with MS\u2010CPCs show marginal improvement in cardiac function compared to CPCs only. Overall, a straightforward and translational approach is developed to increase the retention of stem cells in the ischemic myocardium. Even though the current biomaterial setup with CPCs as cell source does not translate into improved therapeutic action, coupling this developed technology with stem cell\u2010derived cardiomyocytes can lead to an effective remuscularization therapy.<\/jats:p>","DOI":"10.1002\/adhm.201500861","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T22:08:34Z","timestamp":1456438114000},"page":"1071-1079","source":"Crossref","is-referenced-by-count":50,"title":["Gelatin Microspheres as Vehicle for Cardiac Progenitor Cells Delivery to the Myocardium"],"prefix":"10.1002","volume":"5","author":[{"given":"Dries A. 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