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This vulnerable position calls for urgent identification of novel antiseptic agents. Recently, the ability of a deep eutectic, <jats:bold>C<\/jats:bold>holine <jats:bold>A<\/jats:bold>nd <jats:bold>Ge<\/jats:bold>ranate (CAGE), to treat biofilms of <jats:italic>Pseudomonas aeruginosa<\/jats:italic> and <jats:italic>Salmonella enterica<\/jats:italic> was demonstrated. Here it is reported that CAGE exhibits broad\u2010spectrum antimicrobial activity against a number of drug\u2010resistant bacteria, fungi, and viruses including clinical isolates of <jats:italic>Mycobacterium tuberculosis<\/jats:italic>, <jats:italic>Staphylococcus aureus<\/jats:italic>, and <jats:italic>Candida albicans<\/jats:italic> as well as laboratory strains of Herpes Simplex Virus. Studies in human keratinocytes and mice show that CAGE affords negligible local or systemic toxicity, and an \u2248180\u201314 000\u2010fold improved efficacy\/toxicity ratio over currently used antiseptic agents. Further, CAGE penetrates deep into the dermis and treats pathogens located in deep skin layers as confirmed by the ability of CAGE in vivo to treat <jats:italic>Propionibacterium acnes<\/jats:italic> infection. In combination, the results clearly demonstrate CAGE holds promise as a transformative platform antiseptic agent for preventive as well as therapeutic applications.<\/jats:p>","DOI":"10.1002\/adhm.201600086","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T17:28:02Z","timestamp":1457544482000},"page":"1282-1289","source":"Crossref","is-referenced-by-count":167,"title":["Choline and Geranate Deep Eutectic Solvent as a Broad\u2010Spectrum Antiseptic Agent for Preventive and Therapeutic Applications"],"prefix":"10.1002","volume":"5","author":[{"given":"Michael","family":"Zakrewsky","sequence":"first","affiliation":[{"name":"Center for Bioengineering and Department of Chemical Engineering University of California Santa Barbara  Santa Barbara CA 93106 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Center for Bioengineering and Department of Chemical Engineering University of California Santa Barbara  Santa Barbara CA 93106 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjana","family":"Apte","sequence":"additional","affiliation":[{"name":"Center for Bioengineering and Department of Chemical Engineering University of California Santa Barbara  Santa Barbara CA 93106 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa L.","family":"Kern","sequence":"additional","affiliation":[{"name":"Bioenergy and Biome Science Group Bioscience Division Los Alamos National Laboratory  Los Alamos NM 87545 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattie R.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Physical Sciences \u2013 Chemistry Dixie State University  Saint George UT 84770 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rico E. 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