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Fluorescent carbon quantum dots (CQDs) are synthesized by pyrolysis of ammonium citrate in the solid state and then modified with spermidine by a simple heating treatment without a coupling agent. Spermidine, a naturally occurring polyamine, binds with DNA, lipids, and proteins involved in many important processes within organisms such as DNA stability, and cell growth, proliferation, and death. The antimicrobial activity of the as\u2010synthesized Spd\u2013CQDs (size \u22484.6 nm) has been tested against non\u2010multidrug\u2010resistant <jats:italic>E. coli<\/jats:italic>, <jats:italic>S. aureus<\/jats:italic>, <jats:italic>B. subtilis<\/jats:italic>, and <jats:italic>P. aeruginosa<\/jats:italic> bacteria and also multidrug\u2010resistant bacteria, <jats:italic>methicillin\u2010resistant S. aureus<\/jats:italic> (MRSA). The minimal inhibitory concentration value of Spd\u2013CQDs is much lower (&gt;25 000\u2010fold) than that of spermidine, indicating their promising antibacterial characteristics. The mechanism of antibacterial activity is investigated, and the results indicate that Spd\u2013CQDs cause significant damage to the bacterial membrane. In vitro cytotoxicity and hemolysis analyses reveal the high biocompatibility of Spd\u2013CQDs. To demonstrate its practical application, in vitro MRSA\u2010infected wound healing studies in rats have been conducted, which show faster healing, better epithelialization, and formation of collagen fibers when Spd\u2013CQDs are used as a dressing material.<\/jats:p>","DOI":"10.1002\/adhm.201600297","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T08:58:43Z","timestamp":1469177923000},"page":"2545-2554","source":"Crossref","is-referenced-by-count":203,"title":["Synthesis of Self\u2010Assembled Spermidine\u2010Carbon Quantum Dots Effective against Multidrug\u2010Resistant Bacteria"],"prefix":"10.1002","volume":"5","author":[{"given":"Yu\u2010Jia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Bioscience and Biotechnology National Taiwan Ocean University  Keelung 20224 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott G.","family":"Harroun","sequence":"additional","affiliation":[{"name":"Department 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