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Herein, the results of a small diameter (ID \u2248 1 mm) vascular graft constructed from resorbable, amino acid\u2010based poly(ester urea) (PEU) are reported. Electrospun PEU grafts of two different wall thicknesses (type A: 250 \u03bcm; type B: 350 \u03bcm) are implanted as abdominal infra\u2010renal aortic grafts in a severe combined immune deficient\/beige mouse model and evaluated for vessel remodeling over one year. Significantly, the small diameter TEVG does not rupture or lead to acute thrombogenic events during the intervals tested. The pilot TEVG in vivo shows long\u2010term patency and extensive tissue remodeling with type A grafts. Extensive tissue remodeling in type A grafts leads to the development of well\u2010circumscribed neovessels with an endothelial inner lining, a neointima containing smooth muscle cells. However, due to slow degradation of the PEU scaffold materials in vivo, the grafts remain after one year. The type B grafts, which have 350 \u03bcm thick walls, experience occlusion over the one year interval due to intimal hyperplasia. This study affords significant findings that will guide the design of future generations of small diameter vascular grafts.<\/jats:p>","DOI":"10.1002\/adhm.201600400","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T06:06:54Z","timestamp":1467958014000},"page":"2427-2436","source":"Crossref","is-referenced-by-count":35,"title":["Pilot Mouse Study of 1 mm Inner Diameter (ID) Vascular Graft Using Electrospun Poly(ester urea) Nanofibers"],"prefix":"10.1002","volume":"5","author":[{"given":"Yaohua","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Polymer Science The University of Akron  Akron OH 44325 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Surgery Nationwide Children's Hospital  Columbus OH 43205 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Shinoka","sequence":"additional","affiliation":[{"name":"Department of Surgery Nationwide Children's Hospital  Columbus OH 43205 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Ung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Nationwide Children's Hospital  Columbus OH 43205 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell H.","family":"Reneker","sequence":"additional","affiliation":[{"name":"Department of Polymer Science The University of Akron  Akron OH 44325 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K.","family":"Breuer","sequence":"additional","affiliation":[{"name":"Department of Surgery Nationwide Children's Hospital  Columbus OH 43205 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Polymer Science The University of Akron  Akron OH 44325 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,8]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc4701.099488"},{"key":"e_1_2_6_2_1","first-page":"726158","author":"Diodato M.","year":"2014","journal-title":"Surg. 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