{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:55:30Z","timestamp":1791431730529,"version":"4.3.3"},"reference-count":42,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Nature Science Foundations of China","award":["31370936"],"award-info":[{"award-number":["31370936"]}]},{"name":"State Key Development Program for Basic Research of China","award":["2010CB529106"],"award-info":[{"award-number":["2010CB529106"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>Peptide\u2010based therapy, such as modified peptides, has attracted increased attention. IL\u201017 is a promising therapeutic target for autoimmune diseases, and levels of circulating bioactive IL\u201017 are associated with rheumatoid arthritis severity. In this study, a modified truncated IL\u201017RC is generated to ameliorate inflammation and bone destruction in arthritis. The truncated IL\u201017RC binds to both IL\u201017A and IL\u201017F with higher binding capacity compared to nonmodified IL\u201017RC. In addition, the truncated IL\u201017RC reduces the secretion of inflammatory and osteoclastogenic factors induced by IL\u201017A\/F in vitro. Moreover, the administration of truncated IL\u201017RC dramatically improves symptoms of inflammation and inhibited bone destruction in collagen\u2010induced arthritis mice. Collectively, these data demonstrate that modified truncated IL\u201017RC peptide may be a more effective treatment strategy in the simultaneous inhibition of both IL\u201017A and IL\u201017F signaling, whereas the existing agents neutralize IL\u201017A or IL\u201017F alone. These suggest that the truncated IL\u201017RC may be a potential candidate in the treatment of inflammatory associated bone diseases.<\/jats:p>","DOI":"10.1002\/adhm.201600668","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T19:01:32Z","timestamp":1476298892000},"page":"2911-2921","source":"Crossref","is-referenced-by-count":13,"title":["A Truncated IL\u201017RC Peptide Ameliorates Synovitis and Bone Destruction of Arthritic Mice"],"prefix":"10.1002","volume":"5","author":[{"given":"Yuxuan","family":"Du","sequence":"first","affiliation":[{"name":"Department of Immunology School of Basic Medical Sciences Capital Medical University  No. 10 Xitoutiao, You An Men Beijing 100069 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Basic Medical Sciences Capital Medical University  No. 10 Xitoutiao, You An Men Beijing 100069 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentong","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Basic Medical Sciences Capital Medical University  No. 10 Xitoutiao, You An Men Beijing 100069 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Blood transfusion Aerospace Center Hospital  No.15, Yuquan Road Haidian District Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglin","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Basic Medical Sciences Capital Medical University  No. 10 Xitoutiao, You An Men Beijing 100069 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Basic Medical Sciences Capital Medical University  No. 10 Xitoutiao, You An Men Beijing 100069 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Basic Medical Sciences Capital Medical University  No. 10 Xitoutiao, You An Men Beijing 100069 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shentao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Basic Medical Sciences Capital Medical University  No. 10 Xitoutiao, You An Men Beijing 100069 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanguo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology &amp; Immunology Clinical Immunology Center Peking University People's Hospital  No. 11 Xizhimen South Street Beijing 100044 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Alexander","family":"Stinson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Rheumatology University of Michigan  Ann Arbor MI 48109 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Basic Medical Sciences Capital Medical University  No. 10 Xitoutiao, You An Men Beijing 100069 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Basic Medical Sciences Capital Medical University  No. 10 Xitoutiao, You An Men Beijing 100069 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,6]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01661"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.012"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2013.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.09.014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.03.014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308809200"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344184"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545910"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39414"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200106)44:6<1293::AID-ART221>3.0.CO;2-T"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2009.12.011"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2010.10.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62961-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22326"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-009-0185-0"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.132233"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2586"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.8.5462"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-014-0426-z"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(03)00002-9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6145810"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20001"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2805"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2012.11.012"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34680"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-011-1737-y"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0710-6"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1054-8"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00699.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.143768"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1033"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-013-0810-x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23206"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12950-015-0056-5"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.19"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203371"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080169"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-012-0534-7"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2011.07.003"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.07.047"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2015.34"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2015.16.2.165"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadhm.201600668","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadhm.201600668","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.201600668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:50:07Z","timestamp":1759776607000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.201600668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,6]]},"references-count":42,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1002\/adhm.201600668"],"URL":"https:\/\/doi.org\/10.1002\/adhm.201600668","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,6]]}}}