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Although antibiotics have commonly been used to treat acne, antibiotic resistance of <jats:italic>P. acnes<\/jats:italic> is an emerging issue to be solved. In this study, a new way of photodynamic acne therapy is developed using <jats:italic>P. acnes<\/jats:italic> lipase\u2010sensitive transfersome (DSPE\u2010PEG\u2010Pheo A (DPP) transfersome). For enhanced selectivity and skin penetration efficiency, DPP transfersomes are prepared from 1,2\u2010distearoyl\u2010<jats:italic>sn<\/jats:italic>\u2010glycero\u20103\u2010phosphoethanolamine\u2010<jats:italic>N<\/jats:italic>\u2010[amino(polyethylene glycol)\u20102000], pheophorbide A (Pheo A), cholesterol, and Tween\u201080. Incorporation of Tween\u201080 as an edge activator increases the deformability of DPP transfersomes, enhancing skin penetration efficiency to four times that of free Pheo A. The photoactivity of Pheo A quenched by DPP transfersomes is gradually recovered by selective cleavage of the ester linkage in DPP transfersomes by <jats:italic>P. acnes<\/jats:italic> lipases. In vitro <jats:italic>P. acnes<\/jats:italic>\u2010specific photoactivity and subsequent selective antimicrobial effect exhibit a greater than 99% loss of <jats:italic>P. acnes<\/jats:italic> viability. In vivo antiacne therapeutic effect is confirmed by reduction of swelling volume and thickness of <jats:italic>P. acnes<\/jats:italic>\u2010induced nude mice skin. These results demonstrate that DPP transfersome\u2010mediated photodynamic therapy can be used as an alternative method to treat bacterial skin infections.<\/jats:p>","DOI":"10.1002\/adhm.201600815","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T12:55:25Z","timestamp":1478782525000},"page":"3139-3147","source":"Crossref","is-referenced-by-count":44,"title":["Lipase\u2010Sensitive Transfersomes Based on Photosensitizer\/Polymerizable Lipid Conjugate for Selective Antimicrobial Photodynamic Therapy of Acne"],"prefix":"10.1002","volume":"5","author":[{"given":"Hyung","family":"Park","sequence":"first","affiliation":[{"name":"Center for Photomedicine Department of Biotechnology The Catholic University of Korea  43 Jibong\u2010ro, Wonmi\u2010gu Bucheon\u2010si Gyeonggi\u2010do 420\u2010743 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonghwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for 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