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In the present study, polycaprolactone (PCL) conduits are coated with Naphthalene\u2010phenylalanine\u2010phenylalanine\u2010glycine\u2010arginine\u2010glycine\u2010aspartic (Nap\u2010FFGRGD) and Naphthalene\u2010phenylalanine\u2010phenylalanine\u2010glycine\u2010cysteine\u2010aspartic\u2010proline\u2010glycine\u2010tyrosine\u2010isoleucine\u2010glycine\u2010serine\u2010arginine (Nap\u2010FFGCDPGYIGSR) by self\u2010assembly. In vitro studies demonstrate that arginine\u2010glycine\u2010aspartic (RGD) and tyrosine\u2010isoleucine\u2010glycine\u2010serine\u2010arginine (YIGSR) are capable of synergistically enhancing the ability of PCL to support the adhesion and proliferation of Schwann cells, as well as increasing neurite outgrowth from dorsal root ganglions explants. This synergistic effect may occur via the activation of both the phosphoinositide 3\u2010kinase\/protein kinase B and mitogen\u2010activated protein kinase\/extracellular signal\u2010regulated protein kinase pathways. RGD\/YIGSR modifications demonstrate beneficial effects across a 15 mm sciatic nerve gap in axonal regeneration and functional recovery. In addition, increased vascularization is observed in the RGD\/YIGSR\u2010PCL group, which might contribute to their beneficial effects on nerve regeneration. These findings indicate the potential of the RGD\/YIGSR\u2010PCL conduit to promote axonal regeneration and functional recovery, making the RGD\/YIGSR\u2010PCL conduit an attractive candidate for the treatment of a critical nerve defect.<\/jats:p>","DOI":"10.1002\/adhm.201600860","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T09:10:53Z","timestamp":1485853853000},"source":"Crossref","is-referenced-by-count":85,"title":["Noncovalent Bonding of RGD and YIGSR to an Electrospun Poly(\u03b5\u2010Caprolactone) Conduit through Peptide Self\u2010Assembly to Synergistically Promote Sciatic Nerve Regeneration in Rats"],"prefix":"10.1002","volume":"6","author":[{"given":"Lei","family":"Zhu","sequence":"first","affiliation":[{"name":"Institute of Orthopaedics Xijing Hospital The Fourth Military Medical University  Xi'an Shaanxi 710032 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