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However, one key element and technical challenge of those systems is to selectively target them to cancer cells. As a proof\u2010of\u2010concept, Prickly zinc\u2010doped copper oxide (Zn\u2013CuO) nanoparticles (Prickly NPs) have been synthesized, and subsequently encapsulated in a pH\u2010responsive polymer; and the surface has been modified with a novel synthesized ligand, 3\u2010(cyclooctylamino)\u20102,5,6\u2010trifluoro\u20104\u2010[(2\u2010hydroxyethyl)sulfonyl] benzenesulfonamide (VD1142). The Prickly NPs exhibit very effective cancer cell antiproliferative capability. Moreover, the polymer encapsulation shields the Prickly NPs from unspecific nanopiercing and, most importantly, VD1142 endows the engineered NPs to specifically target to the carbonic anhydrase IX, a transmembrane protein overexpressed in a wide variety of cancer tumors. Intracellularly, the Prickly NPs disintegrate into small pieces that upon endosomal escape cause severe damage to the endoplasmic reticulum and mitochondria of the cells. The engineered Prickly NP is promising in efficient and targeted cancer treatment and it opens new avenue in nanomedication.<\/jats:p>","DOI":"10.1002\/adhm.201601406","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T05:26:48Z","timestamp":1488950808000},"source":"Crossref","is-referenced-by-count":44,"title":["Microfluidic Encapsulation of Prickly Zinc\u2010Doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy"],"prefix":"10.1002","volume":"6","author":[{"given":"Hongbo","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki  FI\u201000014 Helsinki Finland"},{"name":"Harvard John A. 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