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These polymers demonstrate activity against clinically relevant Gram\u2010positive <jats:italic>Staphylococcus epidermidis<\/jats:italic> and <jats:italic>Staphylococcus aureus<\/jats:italic>, Gram\u2010negative <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, and fungus <jats:italic>Candida albicans<\/jats:italic> with fast killing kinetics. Importantly, the polymer efficiently inhibits biofilm growth and lyses existing biofilm, leading to a reduction in biomass and cell viability. In addition, the macromolecular antimicrobial is less likely to induce resistance as it acts via a membrane\u2010lytic mechanism. The polymer is not cytotoxic toward mammalian cells with LD<jats:sub>50<\/jats:sub> of 99.0 \u00b1 11.6 mg kg<jats:sup>\u22121<\/jats:sup> in mice through i.v. injection. In an <jats:italic>S. aureus<\/jats:italic> blood stream infection mouse model, the polymer removes bacteria from the blood more rapidly than the antibiotic Augmentin. At the effective dose, the polymer treatment does not damage liver and kidney tissues or functions. In addition, blood electrolyte balance remains unchanged after the treatment. The low cost of starting materials, ease of synthesis, nontoxicity, broad spectrum activity with fast killing kinetics, and in vivo antimicrobial activity make these macromolecular antimicrobials ideal candidates for prevention of sepsis and treatment of infections.<\/jats:p>","DOI":"10.1002\/adhm.201601420","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T08:22:55Z","timestamp":1494836575000},"source":"Crossref","is-referenced-by-count":43,"title":["Broad Spectrum Macromolecular Antimicrobials with Biofilm Disruption Capability and In Vivo Efficacy"],"prefix":"10.1002","volume":"6","author":[{"given":"Jeremy P. 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