{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T20:12:44Z","timestamp":1769026364012,"version":"3.49.0"},"reference-count":85,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T00:00:00Z","timestamp":1499731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31470947"],"award-info":[{"award-number":["31470947"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004602","name":"Program for New Century Excellent Talents in University","doi-asserted-by":"publisher","award":["NCET\u201013\u20100385"],"award-info":[{"award-number":["NCET\u201013\u20100385"]}],"id":[{"id":"10.13039\/501100004602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Extracellularmatrix (ECM)\u2010based scaffolds are important for their potential therapeutic application. Treated dentin matrix (TDM), a kind of ECM, seeded with allogeneic dental follicle stem cells (TDM\/aDFC) provides a suitable inductive microenvironment for tooth root regeneration. Considering the limited sources, xenogeneic TDM (xTDM) is a possible alternative to allogeneic TDM; however, xTDM\u2010based scaffold presents severe osteolysis and resorption lacunae causing regenerated tooth root failure. Immune response\u2013induced excessive osteoclastogenesis plays a critical role in xenogeneic scaffold osteolysis and resorption. The impact of antioxidant, <jats:italic>tert<\/jats:italic>\u2010butylhydroquinone (<jats:italic>t<\/jats:italic>BHQ), on xTDM\/aDFCs\u2010induced osteoclastogenesis and osteoclastic resorption in vivo and in vitro are investigated. <jats:italic>t<\/jats:italic>BHQ upregulates heme oxygenase\u20101 release and downregulates high mobility group box 1 mRNA expression. mRNA expression of other osteoclast\u2010related genes including nuclear factor\u2010kappa Bp65, receptor activator of nuclear factor kappa\u2010B, nuclear factor of activated T\u2010cells cytoplasmic 1, cathepsin K, and integrin \u03b23, also decreases significantly. Furthermore, <jats:italic>t<\/jats:italic>BHQ\u2010treated xTDM\/aDFCs scaffolds implanted into rhesus macaques show reduced osteolysis and osteoclastic resorption by microcomputed tomography and tartrate\u2010resistant acid phosphatase staining. <jats:italic>t<\/jats:italic>BHQ\u2010induced suppression of xTDM\/aDFC\u2010induced osteoclastogenesis and osteoclastic resorption presents a new strategy for the regeneration of biological tooth root and could be applied to the regeneration of other complex tissues and organs.<\/jats:p>","DOI":"10.1002\/adhm.201700127","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T08:52:07Z","timestamp":1499763127000},"source":"Crossref","is-referenced-by-count":22,"title":["<i>t<\/i>BHQ Suppresses Osteoclastic Resorption in Xenogeneic\u2010Treated Dentin Matrix\u2010Based Scaffolds"],"prefix":"10.1002","volume":"6","author":[{"given":"Jingjing","family":"Sun","sequence":"first","affiliation":[{"name":"National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University  Chengdu 610041 China"},{"name":"Department of Oral and Maxillofacial Surgery West China School of Stomatology Sichuan University  Chengdu 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University  Chengdu 610041 China"},{"name":"Department of Oral and Maxillofacial Surgery West China School of Stomatology Sichuan University  Chengdu 610041 China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences College of Stomatology Chongqing Medical University  Chongqing 401147 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University  Chengdu 610041 China"},{"name":"Department of Oral and Maxillofacial Surgery West China School of Stomatology Sichuan University  Chengdu 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hefeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dental Research The Affiliated Stomatological Hospital of Kunming Medical University  Kunming 650031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinlong","family":"Chen","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University  Chengdu 610041 China"},{"name":"Department of Oral and Maxillofacial Surgery West China School of Stomatology Sichuan University  Chengdu 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University  Chengdu 610041 China"},{"name":"Department of Oral and Maxillofacial Surgery West China School of Stomatology Sichuan University  Chengdu 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangjun","family":"Huo","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University  Chengdu 610041 China"},{"name":"Department of Oral and Maxillofacial Surgery West China School of Stomatology Sichuan University  Chengdu 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Guo","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University  Chengdu 610041 China"},{"name":"Department of Oral and Maxillofacial Surgery West China School of Stomatology Sichuan University  Chengdu 610041 China"},{"name":"Department of Pediatric Dentistry West China School of Stomatology Sichuan University  Chengdu 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Tian","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University  Chengdu 610041 China"},{"name":"Department of Oral and Maxillofacial Surgery West China School of Stomatology Sichuan University  Chengdu 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,11]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.09.018"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60073-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2013.11.003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.12.055"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.10.030"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.02.040"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2003.12.016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.04.043"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.07.032"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.03.043"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2014.0043"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.02.011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.03.062"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-016-5780-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2014.02.025"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2015.10.002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201601112"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2010.09.012"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.134189"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9204574"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v6.i5.526"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-013-0963-7"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.1874"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.11.003"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.1874"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.01.028"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/35046196"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008207.2016.1140152"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.09.023"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11176"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2014.55.5.1165"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13275"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22858"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080234"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4278fje"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2015.03.022"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.10.031"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-006-9094-2"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2015.12.042"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/502564"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920007779315035"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097685"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx1004369"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23372"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2827"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.03.008"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.09.068"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.03.016"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.11.074"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2008.09.013"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.11.078"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.931140"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.01.028"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.2144\/000113754"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10763"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12380"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/281287"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1885"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600253"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090533"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3669"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.568360"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0229-4"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.04.006"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22977"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.05.034"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162728"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.12.013"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2013.00027"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.04.073"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.141"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318293b7e1"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132603"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.11.001"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.4161\/viru.2.2.15480"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000225404.51320.82"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048795"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00888"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600564"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.11.046"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.4161\/biom.21563"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-013-9786-7"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.09.045"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130212.x"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12701"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadhm.201700127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.201700127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.201700127","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.201700127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:04:53Z","timestamp":1759781093000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.201700127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,11]]},"references-count":85,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1002\/adhm.201700127"],"URL":"https:\/\/doi.org\/10.1002\/adhm.201700127","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,11]]},"article-number":"1700127"}}